Engineering Stem Cells for Biomedical Applications.
Engineering Stem Cells for Biomedical Applications.
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DOI：
10.1002/adhm.201400842
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发表时间：
2016-01-07
影响因子：
10
通讯作者：
Lee KB
中科院分区：
文献类型：
--
作者：
Yin PT;Han E;Lee KB
干细胞的特征在于许多有用的性质，包括它们迁移、分化和分泌多种治疗分子如免疫调节因子的能力。因此，许多临床前和临床研究已经利用了基于干细胞的疗法，并证明了其治疗各种人类疾病和病症的巨大潜力。最近，努力集中在工程干细胞，以进一步增强其先天能力，以及赋予它们新的功能，然后可以用于各种生物医学应用。这些工程干细胞可以采取多种形式。例如，工程化干细胞包括干细胞的遗传修饰以及干细胞用于基因递送、纳米颗粒装载和递送、甚至小分子药物递送的用途。本综述深入介绍了工程干细胞的现状，包括潜在的细胞来源，用于工程干细胞的最常见方法，以及工程干细胞在各种生物医学应用中的利用，特别关注组织再生，免疫缺陷疾病和癌症的治疗。
Stem cells are characterized by a number of useful properties, including their ability to migrate, differentiate, and secrete a variety of therapeutic molecules such as immunomodulatory factors. As such, numerous pre-clinical and clinical studies have utilized stem cell-based therapies and demonstrated their tremendous potential for the treatment of various human diseases and disorders. Recently, efforts have focused on engineering stem cells in order to further enhance their innate abilities as well as to confer them with new functionalities, which can then be used in various biomedical applications. These engineered stem cells can take on a number of forms. For instance, engineered stem cells encompass the genetic modification of stem cells as well as the use of stem cells for gene delivery, nanoparticle loading and delivery, and even small molecule drug delivery. The present Review gives an in-depth account of the current status of engineered stem cells, including potential cell sources, the most common methods used to engineer stem cells, and the utilization of engineered stem cells in various biomedical applications, with a particular focus on tissue regeneration, the treatment of immunodeficiency diseases, and cancer.
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影响因子：
4.9
作者：
Ahmed AU;Tyler MA;Thaci B;Alexiades NG;Han Y;Ulasov IV;Lesniak MS
通讯作者：
Lesniak MS
影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
12.4
作者：
Ahmed, Atique U.;Rolle, Cleo E.;Lesniak, Maciej S.
通讯作者：
Lesniak, Maciej S.
影响因子：
11.2
作者：
Bang, OY;Lee, JS;Lee, G
通讯作者：
Lee, G
DOI：
10.1073/pnas.0306431101
发表时间：
2004-03-09
影响因子：
11.1
作者：
Asheuer, M;Pflumio, FO;Cartier, N
通讯作者：
Cartier, N