Chitin nanocrystal enhanced wet adhesion performance of mussel-inspired citrate-based soft-tissue adhesive.
Chitin nanocrystal enhanced wet adhesion performance of mussel-inspired citrate-based soft-tissue adhesive.
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DOI：
10.1016/j.carbpol.2018.03.005
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发表时间：
2018-06
影响因子：
11.2
通讯作者：
Yiwen Xu;K. Liang;Wajeeh Ullah;Yali Ji;Jinghong Ma
中科院分区：
文献类型：
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作者：
Yiwen Xu;K. Liang;Wajeeh Ullah;Yali Ji;Jinghong Ma
甲壳素纳米粒子（ChiNC）具有良好的生物降解性和生物相容性以及棒状结构特征，是提高生物医用高分子材料力学性能和生物活性的优良纳米填料之一。为了进一步拓展其应用领域，我们将ChiNC分散到一种新合成的柠檬酸盐基组织粘合剂（POEC-d）中，并探讨其对粘合剂粘附性和细胞相容性的影响。以1，8-辛二醇、聚环氧乙烷（PEO）、柠檬酸（CA）和多巴胺（DA）为原料，采用一锅法熔融缩聚制备了贻贝型湿胶POEC-d。POEC-d良好的水溶性使ChiNC和POEC-d易于共混，最终得到POEC-d/ChiNC纳米复合胶粘剂。结果表明，ChiNCs在POEC-d基体中分散良好，并赋予粘合剂额外的交联，以提高本体内聚性能。同时，通过粘合湿猪皮测量的搭接剪切粘合强度随着ChiNC含量的增加而显著提高。此外，POEC-d/ChiNC纳米复合材料粘合剂表现出较低的溶胀比相比，POEC-d粘合剂以及良好的细胞相容性，揭示了其上级的软组织粘附的适用性。
Chitin nanocrystal (ChiNC) with its good biodegradability and biocompatibility as well as rod-like structure characteristic has become one of excellent nanofillers to enhance mechanical properties and bioactivity of biomedical polymers. For further extending its application fields, here, we dispersed ChiNC into a recently synthesized citrate-based tissue adhesive (POEC-d) and explored its effects on the adhesion and cytocompatibility of the adhesive. POEC-d, a mussel-inspired wet adhesive, was prepared by a one-pot melt polycondensation of 1, 8-octanediol, poly(ethylene oxide) (PEO), citric acid (CA) and dopamine (DA). The good water-solubility of POEC-d allowed facilely blending ChiNC and POEC-d to ultimately acquire POEC-d/ChiNC nanocomposite adhesives. The results showed the ChiNCs were finely dispersed in the POEC-d matrix and endowed the adhesive with extra crosslinks to enhance the bulk cohesion property. Synchronously, the lap-shear adhesion strengths measured by bonding wet porcine skins considerably improved with increasing the ChiNC content. In addition, the POEC-d/ChiNC nanocomposite adhesives exhibited lower swelling ratio as compared to the POEC-d adhesive as well as good cytocompatibility, revealing their superior applicability in soft-tissue adhesion.