BCM-Type Synaptic Plasticity Model Using a Linear Summation of Calcium Elevations as a Sliding Threshold
BCM-Type Synaptic Plasticity Model Using a Linear Summation of Calcium Elevations as a Sliding Threshold
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DOI：
10.1007/11893028_3
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发表时间：
2006-10
期刊：
影响因子：
--
通讯作者：
Hiroki Kurashige;Y. Sakai
中科院分区：
文献类型：
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作者：
Hiroki Kurashige;Y. Sakai
人们认为，突触棘中钙升高的量决定了突触是增强还是抑制。然而，已经指出，简单地应用该原理不能再现尖峰时间依赖可塑性（STDP）的特性。为了解决这个问题，我们提出了一种可能的机制，使用动态滑动阈值作为单个突触前和突触后锋电位引起的钙升高的线性总和。我们证明，该模型可以重现生物STDP的时间依赖性。此外，我们发现，该模型可以重现依赖的生物STDP的初始突触强度，这被发现是不对称的突触增强和抑郁症，而没有明确的初始强度依赖，也没有不对称的机制被纳入模型。
It has been considered that an amount of calcium elevation in a synaptic spine determines whether the synapse is potentiated or depressed. However, it has been pointed out that simple application of the principle can not reproduce properties of spike-timing-dependent plasticity (STDP). To solve the problem, we present a possible mechanism using dynamically sliding threshold as the linear summation of calcium elevations induced by single pre-synaptic and post-synaptic spikes. We demonstrate that the model can reproduce the timing dependence of biological STDP. In addition, we find that the model can reproduce the dependence of biological STDP on the initial synaptic strength, which is found to be asymmetric for synaptic potentiation and depression, whereas no explicit initial-strength dependence nor asymmetric mechanism are incorporated into the model.