Adaptive stress response of glutathione and uric acid metabolism in man following controlled exercise and diet.
Adaptive stress response of glutathione and uric acid metabolism in man following controlled exercise and diet.
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控制运动和饮食后人类谷胱甘肽和尿酸代谢的适应性应激反应。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
A. Sjödin
中科院分区：
文献类型：
--
作者：
M. Svensson;B. Ekblom;I. Cotgreave;B. Norman;B. Sjöberg;Ö. Ekblom;B. Sjödin;A. Sjödin
研究了15名健康年轻男性受试者(VO(2max)约54.7mL kg(-1)min(-1)，年龄约25岁)在高(能量摄入量的62%)或低(能量摄入量的26%)饮食摄入的3天控制性超负荷训练前后骨骼肌(SM)能量中间产物和谷胱甘肽(GSH)代谢的急性运动诱发变化。摄入碳水化合物丰富的饮食明显减少了短期训练期后SM糖原的消耗，与耐力表现的积极作用平行，但对高强度工作表现没有影响。无论饮食中的碳水化合物含量和SM中的基础糖原水平如何，在从短期训练期恢复2.5天后，观察到了一种被定义为工作表现受损的延迟过度效应。综上所述，本研究的主要和新颖的发现是：(1)大强度运动导致SM的GSH含量急剧下降，硫醇氧化还原动态平衡发生改变；(2)短期训练期后基础GSH水平呈适应性升高；(3)训练恢复2.5天后基础GSH水平呈适应性下降；(4)有证据表明SM纤维类型、身体运动能力与急性运动中GSH周转之间的关系；(5)碳水化合物摄入水平对GSH或能量中间体的代谢没有明显影响。此外，在反复高强度间歇训练期间，运动性SM的急性氧化应激的诱导和对训练的适应性反应被认为为运动性SM提供了一种保护性的抗氧化剂表型。
Ergometer cycling performance as well as acute exercise-induced changes in the metabolism of energy-intermediates and glutathione (GSH) were investigated in skeletal muscle (SM) of 15 healthy young male subjects (VO(2max) approximately 54.7 mL kg(-1) min(-1), age approximately 25 years), before and after 3 days of controlled 'ìoverload-training' in combination with either high (62% of energy intake) or low (26% of energy intake) dietary intake of carbohydrates. The intake of a carbohydrate-rich diet clearly reduced the depletion of SM glycogen following the short-term training period, paralleled with a positive effect on the endurance performance, but not on high-intensity work-performance. An 'delayed over-reaching effect', defined as impaired work-performance, was observed after 2.5 days of recovery from the short-term training period, irrespective of the carbohydrate content of the diet and basal glycogen level in SM. Taken together, the main and novel findings of present investigation are: (1) an acute decrease of reduced GSH content and altered thiol-redox homeostasis in SM induced by strenuous high-intensity exercise; (2) an adaptive elevation of basal GSH level following the short-term training period; (3) an adaptive decrease of basal GSH level following 2.5 days recovery from training; (4) evidence of a relationship between the SM fibre type, physical performance capacity and GSH turnover during acute bouts of exercise; and (5) no evident effect of the level of carbohydrate intake on metabolism of GSH or energy intermediates. Furthermore, the induction of acute oxidative stress in exercising human SM and the adaptive responses to training are suggested to provide a protective antioxidant phenotype to the exercising SM during periods with repeated intense intermittent training.
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影响因子：
3.3
作者：
Jiankang Liu;H. C. Yeo;Eva Övervik-Douki;T. Hagen;S. Doniger;Daniel W. Chu;George A. Brooks;B. Ames
通讯作者：
Jiankang Liu;H. C. Yeo;Eva Övervik-Douki;T. Hagen;S. Doniger;Daniel W. Chu;George A. Brooks;B. Ames
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
DOI：
10.1152/ajpcell.1994.266.1.c81
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
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作者：
R. V. Dyke;J. Belcher
通讯作者：
R. V. Dyke;J. Belcher
影响因子：
3.3
作者：
WHITE, CW;JACKSON, JH;REPINE, JE
通讯作者：
REPINE, JE
影响因子：
7.4
作者：
Kirlin, WG;Cai, JY;Jones, DP
通讯作者：
Jones, DP