COMPETITIVE ANTAGONISM OF NITRIC-OXIDE SYNTHETASE CAUSES WEIGHT-LOSS IN MICE
COMPETITIVE ANTAGONISM OF NITRIC-OXIDE SYNTHETASE CAUSES WEIGHT-LOSS IN MICE
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DOI：
10.1016/0024-3205(92)90018-k
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发表时间：
1992-01-01
期刊：
影响因子：
6.1
通讯作者：
FLOOD, JF
中科院分区：
文献类型：
--
作者：
MORLEY, JE;FLOOD, JF
这些研究表明，一氧化氮合成的竞争性拮抗剂L-N(G)-硝基-精氨酸甲酯(NO-Arg ME)可使小鼠摄食量的L-精氨酸可逆性减少。NO Arg ME也阻断了强效促食素神经肽Y的摄食作用。给药5天以上，NO Arg ME的体重减轻。研究表明，一氧化氮是食物摄入量的生理调节剂，一氧化氮合酶抑制剂可能对肥胖的管理有用。
These studies demonstrate that the competitive antagonist of nitric oxide synthesis, L-N(G) -nitro-arginine methyl ester (NO Arg ME), produces an L-arginine reversible decrease in food intake in mice. NO Arg ME also blocked the feeding effect of the potent orexigenic peptide, neuropeptide Y. NO Arg ME produced weight loss when administered over 5 days. The studies suggest that nitric oxide is a physiological modulator of food intake and that nitric oxide synthetase inhibitors may be useful in the management of obesity.