Human clinical and histologic responses to the placement of HTR polymer particles in 11 intrabony lesions.
Human clinical and histologic responses to the placement of HTR polymer particles in 11 intrabony lesions.
复制标题
在 11 个骨内病变中放置 HTR 聚合物颗粒的人体临床和组织学反应。
DOI：
10.1902/jop.1990.61.5.269
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发表时间：
1990
影响因子：
4.3
通讯作者：
D. Tarnow
中科院分区：
文献类型：
--
作者：
S. Stahl;S. Froum;D. Tarnow
5名志愿者患者的11处骨内牙周病变接受了外科清创术，然后在部位植入多孔颗粒聚合物复合材料（HTR聚合物）。这些患者的观察时间从4周至26周不等。在个体观察期结束时，通过手术将处理部位块取出进行组织学分析。临床观察表明，治疗后的袋深度减少，包括牙龈退缩和临床闭合的增益。在观察期间，在任何接受治疗的患者中均未观察到临床不良反应。组织学反应从上皮粘附导致的闭合增加到不同程度的新附着不等。在同一患者和患者之间观察到这种不同的反应。移植物颗粒存在于植入后4周至26周的部位，并被结缔组织囊包围。在一些颗粒的外围，存在有限的骨形成。肺泡床正在重塑，有时围绕着特定的颗粒。因此，在我们的样本中，HTR聚合物在植入人体骨内病变时似乎是一种耐受性良好的合成移植材料。
Eleven intrabony periodontal lesions in five volunteer patients received surgical debridement followed by site implantation of a porous particulate polymeric composite (HTR polymer). These patients were observed over time periods varying from 4 weeks to 26 weeks. At the end of the individual observation periods, treated sites were surgically removed in block for histologic analysis. Clinical observations indicated a reduction in pocket depth following treatment which consisted of both gingival recession and gain in clinical closure. No untoward effects were observed clinically in any treated patient during the observation periods. Histologic responses varied from gain in closure by epithelial adhesion to new attachment of varying magnitude. Such varied responses were seen within the same patient and between patients. Graft particles were present at sites from 4 weeks to 26 weeks after implantation and were surrounded by connective tissue capsules. At the periphery of some particles, limited bone formation was present. The alveolar bed was remodeling, at times surrounding specific particles. In our sample, HTR polymer, therefore, appeared to be a well tolerated synthetic graft material when implanted in human intrabony lesions.