Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs
Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs
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DOI：
10.1111/j.1365-2982.2005.00747.x
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发表时间：
2006-02-01
影响因子：
3.5
通讯作者：
Kuwano, H
中科院分区：
文献类型：
--
作者：
Ohno, T;Kamiyama, Y;Kuwano, H
Ghrelin是一种在胃内分泌细胞中发现的肽。然而，其在调节消化道的禁食和进食运动活动中的作用尚未完全了解。在本研究中，我们检查了静脉（i. v.）注射犬生长素释放肽对自由活动的清醒狗的胃、十二指肠、空肠和结肠中的生理性禁食和进食运动活动的影响。静脉注射犬生长激素释放肽以剂量依赖性方式释放生长激素;然而，它在禁食或进食状态下都不刺激消化道的运动活动。此外，静脉注射高剂量的犬生长素释放肽显著降低了禁食状态下胃体的运动指数。Ghrelin也不能加速胃排空。这些结果不同于以往的报告处理啮齿动物。重要的是，这些结果是在对狗的研究中获得的，狗是更大的动物。
Ghrelin is a peptide that was discovered in endocrine cells of the stomach. However, its action in regulating the fasted and fed motor activity of the digestive tract is not fully understood. In the present study, we examined the effects of an intravenous (i.v.) injection of canine ghrelin on the physiological fasted and fed motor activities in the stomach, duodenum, jejunum and colon of freely moving conscious dogs. An i.v. injection of canine ghrelin released growth hormone in a dose-dependent manner; however, it did not stimulate the motor activity of the digestive tract in either the fasted or the fed state. Moreover, an i.v. injection of high-dose canine ghrelin significantly reduced the motility index in the gastric body in the fasted state. Ghrelin did not accelerate gastric emptying, either. These results differ from previous reports dealing with rodents. It is significant that such results were obtained in research with dogs, which are larger animals.