Polyphenols and disease risk in epidemiologic studies
Polyphenols and disease risk in epidemiologic studies
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DOI：
10.1093/ajcn/81.1.317s
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发表时间：
2005-01-01
影响因子：
7.1
通讯作者：
Hollman, PCH
中科院分区：
文献类型：
--
作者：
Arts, ICW;Hollman, PCH
植物多酚是一大类天然抗氧化剂，是解释蔬菜和水果对癌症和心血管疾病的保护作用的重要候选者。流行病学研究对于评估长期暴露于生理浓度的多酚对人类健康的影响是有用的，但是关于食物中多酚含量的可靠数据仍然很少。这篇综述的目的是总结现有的流行病学数据对健康的影响多酚，重点是黄酮类化合物的黄酮醇，黄酮，儿茶素和木脂素。迄今为止获得的数据表明，黄酮类化合物和木脂素对心血管疾病的有益作用，但对癌症没有作用，肺癌可能除外。有必要对中风和哮喘和慢性阻塞性肺病等肺部疾病进行更多的研究。迄今为止，大多数研究仅包括黄酮醇和黄酮。随着其他多酚的数据越来越多，这些化合物应该包括在未来的研究中。前瞻性研究的仔细设计对于弥补流行病学研究的一些主要缺点很重要，包括残留混杂（吸烟和其他饮食因素）和暴露评估。
Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases. Epidemiologic studies are useful for evaluation of the human health effects of long-term exposure to physiologic concentrations of polyphenols, but reliable data on polyphenol contents of foods are still scarce. The aim of this review is to summarize available epidemiologic data on the health effects of polyphenols, focusing on the flavonoid subclasses of flavonols, flavones, and catechins and on lignans. Data obtained to date suggest beneficial effects of both flavonoids and lignans on cardiovascular diseases but not on cancer, with the possible exception of lung cancer. There is a need for more research on stroke and lung diseases such as asthma and chronic obstructive pulmonary disease. Most studies to date have included only flavonols and flavones. With data becoming available for other polyphenols, these compounds should be included in future studies. Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment.