Brain structure in pediatric Tourette syndrome.
Brain structure in pediatric Tourette syndrome.
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DOI：
10.1038/mp.2016.194
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发表时间：
2017-07
影响因子：
11
通讯作者：
The Tourette Association of America Neuroimaging Consortium
中科院分区：
文献类型：
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作者：
Greene DJ;Williams Iii AC;Koller JM;Schlaggar BL;Black KJ;The Tourette Association of America Neuroimaging Consortium
以前对抽动秽语综合征(TS)的大脑结构的研究产生了好坏参半的结果，大多数都是适度的样本量。在目前的多中心研究中，我们使用结构磁共振成像(MRI)对103名患有TS的儿童和青少年与103名没有抽搐的儿童进行了比较。我们应用基于体素的形态计量学方法来测试不同诊断组之间灰质(GM)和白质(WM)体积的差异，包括MRI扫描仪和序列、年龄、性别和GM+WM总体积。TS组双侧眼眶和内侧前额叶皮质WM体积较小，而丘脑后部、下丘脑和中脑GM体积较大。这些结果证明了患有TS的儿童和青少年大脑结构异常的证据，与先前的发现一致并加以扩展，它们指出了TS的新靶区和研究途径。例如，由于眼眶皮质与下丘脑相互联系，这些区域的结构异常可能与TS的异常决策、强化学习或躯体加工有关。本文的在线版本(doi：10.1038/mp.2016.194)包含补充材料，授权用户可以使用。
Previous studies of brain structure in Tourette syndrome (TS) have produced mixed results, and most had modest sample sizes. In the present multicenter study, we used structural magnetic resonance imaging (MRI) to compare 103 children and adolescents with TS to a well-matched group of 103 children without tics. We applied voxel-based morphometry methods to test gray matter (GM) and white matter (WM) volume differences between diagnostic groups, accounting for MRI scanner and sequence, age, sex and total GM+WM volume. The TS group demonstrated lower WM volume bilaterally in orbital and medial prefrontal cortex, and greater GM volume in posterior thalamus, hypothalamus and midbrain. These results demonstrate evidence for abnormal brain structure in children and youth with TS, consistent with and extending previous findings, and they point to new target regions and avenues of study in TS. For example, as orbital cortex is reciprocally connected with hypothalamus, structural abnormalities in these regions may relate to abnormal decision making, reinforcement learning or somatic processing in TS. The online version of this article (doi:10.1038/mp.2016.194) contains supplementary material, which is available to authorized users.