Cross-species transmission of the newly identified coronavirus 2019-nCoV
Cross-species transmission of the newly identified coronavirus 2019-nCoV
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DOI：
10.1002/jmv.25682
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发表时间：
2020-04-01
影响因子：
12.7
通讯作者：
Li, Xingguang
中科院分区：
文献类型：
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作者：
Ji, Wei;Wang, Wei;Li, Xingguang
目前在中国武汉市爆发的病毒性肺炎是由世界卫生组织命名为2019-nCoV的新型冠状病毒引起的，这是通过对病毒RNA基因组测序确定的。许多最初的患者在华南海鲜批发市场接触野生动物，那里也出售家禽，蛇，蝙蝠和其他农场动物。为了研究可能的病毒储库，我们基于2019-nCoV序列，结合不同动物物种之间的相对同义密码子使用（RSCU）偏倚进行了全面的序列分析和比较。从我们的分析中获得的结果表明，2019-nCoV可能是蝙蝠冠状病毒和来源不明的冠状病毒之间的重组病毒。重组可能发生在病毒刺突糖蛋白内，它识别细胞表面受体。此外，我们的研究结果表明，2019-nCoV与蝙蝠冠状病毒具有最相似的遗传信息，与蛇具有最相似的密码子使用偏好。综上所述，我们的研究结果表明，同源重组可能会发生，并有助于2019-nCoV跨物种传播。
The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 2019-nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. Many initial patients were exposed to wildlife animals at the Huanan seafood wholesale market, where poultry, snake, bats, and other farm animals were also sold. To investigate possible virus reservoir, we have carried out comprehensive sequence analysis and comparison in conjunction with relative synonymous codon usage (RSCU) bias among different animal species based on the 2019-nCoV sequence. Results obtained from our analyses suggest that the 2019-nCoV may appear to be a recombinant virus between the bat coronavirus and an origin-unknown coronavirus. The recombination may occurred within the viral spike glycoprotein, which recognizes a cell surface receptor. Additionally, our findings suggest that 2019-nCoV has most similar genetic information with bat coronovirus and most similar codon usage bias with snake. Taken together, our results suggest that homologous recombination may occur and contribute to the 2019-nCoV cross-species transmission.