Quality of life and voice in patients with laryngeal carcinoma:: A posttreatment comparison of laryngectomy (Salvage surgery) versus radiotherapy
Quality of life and voice in patients with laryngeal carcinoma:: A posttreatment comparison of laryngectomy (Salvage surgery) versus radiotherapy
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DOI：
10.1097/00005537-199810000-00027
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发表时间：
1998-10-01
期刊：
影响因子：
2.6
通讯作者：
Lindström, J
中科院分区：
文献类型：
--
作者：
Finizia, C;Hammerlid, E;Lindström, J
目的：本研究旨在比较60例喉癌患者接受根治性放疗联合或不联合喉切除术作为挽救性手术的声音和生活质量（QOL）。我们还比较了患者自己对自己声音的感知评级与一组听众的感知评级。研究设计：两组喉癌患者进行了研究。研究方法：14例保留喉的放射性喉扬声器与14例保留喉的挽救性喉切除术后使用气管食管假体（TEP）说话的患者相匹配。为了测量患者的生活质量，我们使用了欧洲癌症研究和治疗组织生活质量核心问卷（EORTC QLQ-C30），EORTC头颈部模块（EORTC QLQ-H & N35），医院焦虑和抑郁量表（HAD）和研究特定问卷。对于感知语音评估，我们使用视觉模拟量表。结果如下：语音清晰度，语音质量和语音可接受性的感知评级显示治疗组之间的显着差异。接受放射治疗的患者和听众对放射性喉声的评价均高于气管食管语音。喉切除术患者在声嘶问题上的得分明显优于根治性放疗患者。其他生活质量功能和症状无显著差异。结论：当与放疗治疗的患者进行比较，喉切除术作为挽救手术治疗的患者，生活质量是相似的，只有小的差异被发现在知觉的语音评价。
Objectives: This study was designed 60 compare the voice and the quality of life (QOL) of laryngeal cancer patients receiving treatment with radical radiotherapy with or without laryngectomy as salvage surgery. We also compared the patients' own perceptual ratings of their voice to the perceptual ratings of a group of listeners. Study Design: Two groups of laryngeal cancer patients were studied. Methods: Fourteen irradiated laryngeal speakers with preserved larynx were matched with 14 salvage surgery laryngectomized patients speaking with tracheoesophageal prosthesis (TEP). To measure patients' QOL, we used the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30), the EORTC Head and Neck module (EORTC QLQ-H&N35), the Hospital Anxiety and Depression scale (HAD) and a study-specific questionnaire. For the perceptual speech evaluation we used visual analog scales. Results: The perceptual ratings of speech intelligibility, voice quality, and speech acceptability showed a significant difference between the treatment groups. Both the patients who received treatment with radiotherapy and the listeners rated the irradiated laryngeal voices higher than the tracheoesophageal speech. The laryngectomized patients scored significantly better than the patients treated with radical radiotherapy on the question about hoarseness. No other significant difference was found for the QOL functions and symp toms. Conclusion: When patients treated with radiotherapy were compared with patients treated with laryngectomy as salvage surgery, QOL was similar, only small differences being found in the perceptual speech evaluation.