Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing.
Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing.
复制标题
DOI：
10.3390/s150921239
复制
发表时间：
2015-08-28
期刊：
影响因子：
--
通讯作者：
Knoll W
中科院分区：
文献类型：
--
作者：
Boujday S;de la Chapelle ML;Srajer J;Knoll W
In this short summary we summarize some of the latest developments in vibrational spectroscopic tools applied for the sensing of (small) molecules and biomolecules in a label-free mode of operation. We first introduce various concepts for the enhancement of InfraRed spectroscopic techniques, including the principles of Attenuated Total Reflection InfraRed (ATR-IR), (phase-modulated) InfraRed Reflection Absorption Spectroscopy (IRRAS/PM-IRRAS), and Surface Enhanced Infrared Reflection Absorption Spectroscopy (SEIRAS). Particular attention is put on the use of novel nanostructured substrates that allow for the excitation of propagating and localized surface plasmon modes aimed at operating additional enhancement mechanisms. This is then be complemented by the description of the latest development in Surface- and Tip-Enhanced Raman Spectroscopies, again with an emphasis on the detection of small molecules or bioanalytes.
