Verification of Accuracy of CyberKnife Tumor-tracking Radiation Therapy Using Patient-specific Lung Phantoms
Verification of Accuracy of CyberKnife Tumor-tracking Radiation Therapy Using Patient-specific Lung Phantoms
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DOI：
10.1016/j.ijrobp.2015.02.055
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发表时间：
2015-07-15
影响因子：
7
通讯作者：
Cho, Byungchul
中科院分区：
文献类型：
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作者：
Jung, Jinhong;Song, Si Yeol;Cho, Byungchul
目的：研究射波刀Xsight肺跟踪系统（XLTS）的准确性相比，一个基于基准的目标跟踪系统（FTTS）使用patient-specific lung phantomy.Methods和Materials：三维打印技术被用来制作个性化的肺phantomy，密切模仿实际患者的肺解剖结构。基于来自6名使用射波刀接受立体定向消融放射治疗的肺癌患者的计划计算机断层扫描数据，将高于某一Hounsfield单位（HU）的体积指定为通过三维打印机（3D Edison，Lokit，Korea）均匀填充聚乳酸材料的结构。我们使用FTTS和XLTS每次治疗期间生成的3个日志文件评价了测量和建模目标位置之间的差异，代表总跟踪误差。我们还分析了γ指数之间的电影剂量下测量的FTTS和XLTS.Results：FTTS的总跟踪误差的整体平均值和标准差分别为0.36 +/- 0.39毫米，0.15 +/- 0.64毫米，和0.15 +/- 0.62毫米的头尾（CC），左右（LR），前后（AP）组件，分别。对于XLTS，CC、LR和AP部件的平均直径分别为0.38 +/- 0.54 mm、0.13 +/- 0.18 mm和0.14 +/- 0.37 mm。3%，3 mm的标准的平均伽马通过率为100%; 2%，2 mm的标准为99.6%; 1%，1 mm的标准为86.8%。结论：XLTS具有与FTTS相当的分割准确性和较小的总跟踪误差。(C)2015爱思唯尔公司All rights reserved.
Purpose: To investigate the accuracy of the CyberKnife Xsight Lung Tracking System (XLTS) compared with that of a fiducial-based target tracking system (FTTS) using patient-specific lung phantoms.Methods and Materials: Three-dimensional printing technology was used to make individualized lung phantoms that closely mimicked the lung anatomy of actual patients. Based on planning computed tomographic data from 6 lung cancer patients who underwent stereotactic ablative radiation therapy using the CyberKnife, the volume above a certain Hounsfield unit (HU) was assigned as the structure to be filled uniformly with polylactic acid material by a 3-dimensional printer (3D Edison, Lokit, Korea). We evaluated the discrepancies between the measured and modeled target positions, representing the total tracking error, using 3 log files that were generated during each treatment for both the FTTS and the XLTS. We also analyzed the gamma index between the film dose measured under the FTTS and XLTS.Results: The overall mean values and standard deviations of total tracking errors for the FTTS were 0.36 +/- 0.39 mm, 0.15 +/- 0.64 mm, and 0.15 +/- 0.62 mm for the craniocaudal (CC), left-right (LR), and anteroposterior (AP) components, respectively. Those for the XLTS were 0.38 +/- 0.54 mm, 0.13 +/- 0.18 mm, and 0.14 +/- 0.37 mm for the CC, LR, and AP components, respectively. The average of gamma passing rates was 100% for the criteria of 3%, 3 mm; 99.6% for the criteria of 2%, 2 mm; and 86.8% for the criteria of 1%, 1 mm.Conclusions: The XLTS has segmentation accuracy comparable with that of the FTTS and small total tracking errors. (C) 2015 Elsevier Inc. All rights reserved.