Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study.
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study.
复制标题
DOI：
10.1016/j.jaci.2010.03.043
复制
发表时间：
2010-07
影响因子：
14.2
通讯作者：
Litonjua, Augusto A.
中科院分区：
文献类型：
--
作者：
Brehm, John M.;Schuemann, Brooke;Fuhlbrigge, Anne L.;Hollis, Bruce W.;Strunk, Robert C.;Zeiger, Robert S.;Weiss, Scott T.;Litonjua, Augusto A.
哮喘急性发作，最常见的原因是呼吸道感染，是哮喘发病率的主要原因，并构成哮喘相关费用的很大一部分。维生素D状态可能在预防哮喘恶化中发挥作用。评估血清维生素D水平与随后严重哮喘急性发作之间的关系。我们测量了1，024名轻度至中度持续性哮喘儿童的血清中25-羟基维生素D（25（OH）D）水平，这些儿童参加了一项多中心临床试验，随机接受布地奈德，奈多罗米或安慰剂（按需β受体激动剂），儿童哮喘管理计划。使用多变量模型，我们检查了基线维生素D水平和任何住院或急诊科（艾德）访问超过4年的试验之间的关系。35%的受试者维生素D不足，定义为25（OH）D水平≤ 30 ng/ml。平均维生素D水平在非裔美国人中最低，在白人中最高。调整年龄、性别、BMI、收入和治疗组后，维生素D不足与住院或艾德就诊的几率较高相关（比值比[OR] 1.5 [95%置信区间[CI]：1.1 - 1.9] P =0.01）。维生素D不足在患有轻度至中度持续性哮喘的北美儿童人群中很常见，并且与四年内严重加重的几率较高相关。
Asthma exacerbations, most often due to respiratory tract infections, are the leading causes of asthma morbidity and comprise a significant proportion of asthma-related costs. Vitamin D status may play a role in preventing asthma exacerbations. To assess the relationship between serum vitamin D levels and subsequent severe asthma exacerbations. We measured 25-hydroxyvitamin D (25(OH)D) levels in serum collected from 1,024 mild to moderate persistent asthmatic children at the time of enrollment in a multi-center clinical trial of children randomized to receiving budesonide, nedocromil, or placebo (as-needed beta-agonists), the Childhood Asthma Management Program. Using multivariable modeling we examined the relationship between baseline vitamin D level and the odds of any hospitalization or emergency department (ED) visit over the 4 years of the trial. 35% of all subjects were vitamin D insufficient, as defined by a level ≤ 30 ng/ml 25(OH)D. Mean vitamin D levels were lowest in African-American subjects, and highest in whites. After adjusting for age, sex, BMI, income, and treatment group, insufficient vitamin D status was associated with a higher odds of any hospitalization or ED visit (odds ratio [OR] 1.5 [95% confidence interval [CI]: 1.1 – 1.9] P =0.01). Vitamin D insufficiency is common in this population of North American children with mild to moderate persistent asthma, and is associated with higher odds of severe exacerbation over a four year period.
登录
查看更多内容
影响因子：
5
作者：
BRUNEKREEF, B;NOY, D;CLAUSING, P
通讯作者：
CLAUSING, P
影响因子：
56.9
作者：
Liu, PT;Stenger, S;Modlin, RL
通讯作者：
Modlin, RL
影响因子：
3.7
作者：
Liu PT;Schenk M;Walker VP;Dempsey PW;Kanchanapoomi M;Wheelwright M;Vazirnia A;Zhang X;Steinmeyer A;Zügel U;Hollis BW;Cheng G;Modlin RL
通讯作者：
Modlin RL
DOI：
10.1016/j.jsbmb.2006.12.066
发表时间：
2007-03-01
影响因子：
4.1
作者：
Hollis, Bruce W.;Wagner, Carol L.;Binkley, Neil C.
通讯作者：
Binkley, Neil C.
DOI：
10.4049/jimmunol.181.10.7090
发表时间：
2008-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hansdottir S;Monick MM;Hinde SL;Lovan N;Look DC;Hunninghake GW
通讯作者：
Hunninghake GW