The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses.
The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses.
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N6-甲基腺苷修饰在B和C型肝炎病毒生命周期和疾病发病机制中的作用
DOI：
10.1038/s12276-021-00581-3
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发表时间：
2021-03
影响因子：
12.8
通讯作者：
Siddiqui A
中科院分区：
文献类型：
--
作者：
Kim GW;Siddiqui A
N6-甲基腺苷（m6 A）是哺乳动物细胞RNA中最普遍的修饰。m6 A甲基化与基因表达的几个方面的表观遗传调控有关，包括RNA稳定性、剪接、核输出、RNA折叠和翻译活性。m6 A修饰由甲基转移酶（m6 A writers）和脱甲基酶（m6 A erasers）可逆催化，并且m6 A修饰的RNA的动力学由m6 A结合蛋白（m6 A readers）调节。最近，一些研究表明，m6 A甲基化位点已被确定在B肝炎病毒（HBV）的转录本和丙型肝炎病毒（HCV）的RNA基因组。本文就m6 A修饰在HBV/HCV复制中的作用及其在肝病发病机制中的作用作一综述。需要更好地了解m6 A甲基化在HBV和HCV生命周期中的功能，以确定这些修饰在与这些病毒感染相关的肝脏疾病中的作用。进一步研究RNA修饰在B型和C型肝炎感染中的作用可以提高对肝炎相关性肝病的理解。在哺乳动物细胞中发现的最常见的RNA修饰是N6-甲基腺苷（m6 A），它与包括基因调控在内的多种细胞过程有关。在病毒RNA中也发现了这种修饰，促使美国圣地亚哥加州大学的Geon-Woo Kim和Aleem Siddiqui回顾了对肝炎病毒感染期间m6 A修饰的理解。根据病毒RNA的哪一部分被m6 A甲基化，m6 A修饰诱导病毒生命周期的复杂变化。感染B或C型肝炎病毒也会影响宿主细胞RNA中的m6 A修饰，从而影响基因表达并抑制免疫力。这可能会影响慢性肝炎感染期间肝脏疾病和癌症的发展。
N6-methyladenosine (m6A) is the most prevalent modification of mammalian cellular RNAs. m6A methylation is linked to epigenetic regulation of several aspects of gene expression, including RNA stability, splicing, nuclear export, RNA folding, and translational activity. m6A modification is reversibly catalyzed by methyltransferases (m6A writers) and demethylases (m6A erasers), and the dynamics of m6A-modified RNA are regulated by m6A-binding proteins (m6A readers). Recently, several studies have shown that m6A methylation sites have been identified in hepatitis B virus (HBV) transcripts and the hepatitis C virus (HCV) RNA genome. Here, we review the role of m6A modification in HBV/HCV replication and its contribution to liver disease pathogenesis. A better understanding of the functions of m6A methylation in the life cycles of HBV and HCV is required to establish the role of these modifications in liver diseases associated with these viral infections. Further investigations into the role of RNA modifications during hepatitis B and C infections could improve understanding of the hepatitis-associated liver disease. The most common RNA modification found in mammalian cells is N6-methyladenosine (m6A), which is linked to multiple cellular processes including gene regulation. This modification has also been identified in viral RNA, prompting Geon-Woo Kim and Aleem Siddiqui at the University of California, San Diego, USA, to review understanding of m6A modification during hepatitis virus infections. Depending on which part of the viral RNA is m6A-methylated, m6A modification induces complex changes in the viral life cycle. Infection with either hepatitis B or C virus also affects m6A modifications in host cellular RNA, influencing gene expression and inhibiting immunity. This may influence the development of liver disease and cancer during chronic hepatitis infection.
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影响因子：
6.4
作者：
Durbin AF;Wang C;Marcotrigiano J;Gehrke L
通讯作者：
Gehrke L
DOI：
10.1261/rna.064238.117
发表时间：
2018-10
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Kretschmer J;Rao H;Hackert P;Sloan KE;Höbartner C;Bohnsack MT
通讯作者：
Bohnsack MT
YTHDF2 通过直接招募 CCR4-NOT 去腺苷酶复合物来破坏含有 m(6)A 的 RNA 的稳定性。
影响因子：
16.6
作者：
Du, Hao;Zhao, Ya;He, Jinqiu;Zhang, Yao;Xi, Hairui;Liu, Mofang;Ma, Jinbiao;Wu, Ligang
通讯作者：
Wu, Ligang
影响因子：
30.3
作者：
Kennedy EM;Bogerd HP;Kornepati AV;Kang D;Ghoshal D;Marshall JB;Poling BC;Tsai K;Gokhale NS;Horner SM;Cullen BR
通讯作者：
Cullen BR
影响因子：
4.8
作者：
Kim, Geon-Woo;Imam, Hasan;Siddiqui, Aleem
通讯作者：
Siddiqui, Aleem