In vitro activity of OPT-80 against clostridium difcile
In vitro activity of OPT-80 against clostridium difcile
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DOI：
10.1128/aac.48.6.2280-2282.2004
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发表时间：
2004-06-01
影响因子：
4.9
通讯作者：
Rodloff, AC
中科院分区：
文献类型：
--
作者：
Ackermann, G;Löffler, B;Rodloff, AC
艰难梭菌仍然是医院内腹泻的主要原因。报道了C.甲硝唑和万古霉素的难治性以及治疗后患者的频繁复发需要寻找新的物质。本文研究了一种新的大环化合物OPT-80对207 ℃的抗氧化活性.艰难梭菌菌株和针对其它专性厌氧细菌进行了测试。OPT-80对所有C.测试的艰难菌株。
Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.