Actomyosin networks and tissue morphogenesis
Actomyosin networks and tissue morphogenesis
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DOI：
10.1242/dev.091645
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发表时间：
2014-05-01
期刊：
影响因子：
4.6
通讯作者：
Lecuit, Thomas
中科院分区：
文献类型：
--
作者：
Munjal, Akankshi;Lecuit, Thomas
组织形态发生由协调的细胞变形驱动。最近的研究表明，这些细胞形状的变化是由细胞内的收缩网络，包括肌动蛋白丝，肌动蛋白交联剂和肌球蛋白马达。由这种肌动球蛋白网络产生的亚细胞力被精确调节，并通过包含钙粘蛋白或整联蛋白的粘附簇传递到相邻细胞的细胞皮质和细胞外环境。在这里，并在所附的海报，我们提供了一个肌动蛋白驱动的细胞张力驱动组织形态发生的机制，原则和调节的概述。
Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actin filaments, actin cross-linkers and myosin motors. The subcellular forces generated by such actomyosin networks are precisely regulated and are transmitted to the cell cortex of adjacent cells and to the extracellular environment by adhesive clusters comprising cadherins or integrins. Here, and in the accompanying poster, we provide an overview of the mechanics, principles and regulation of actomyosin-driven cellular tension driving tissue morphogenesis.