The dysfunction of T follicular helper cells.
The dysfunction of T follicular helper cells.
复制标题
DOI：
10.1097/coh.0000000000000095
复制
发表时间：
2014-09
影响因子：
4.1
通讯作者：
Perreau M
中科院分区：
文献类型：
--
作者：
Cubas R;Perreau M
滤泡辅助 T (Tfh) 细胞作为 B 细胞帮助的提供者发挥着关键作用，Tfh/B 细胞相互作用功能障碍可能导致自身免疫或免疫缺陷。这些观察结果引起了人们对了解这些细胞在艾滋病毒感染期间如何受到影响以及它们的功能变化如何影响抗体反应的极大兴趣。最近的研究表明，HIV/SIV 感染会影响 Tfh 细胞频率和功能，并表明 Tfh 细胞扰动可能导致 HIV 感染者产生广泛中和抗体 (bNAb) 的效率相对较低。本综述将重点介绍这些最新发现，探讨 Tfh 细胞在 HIV 感染中的作用，以及 HIV 感染对 Tfh 和循环记忆 Tfh (cTfh) 细胞频率和功能的影响。
T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody responses. Recent studies have shown that HIV/SIV infection affects both Tfh-cell frequency and function and suggest that Tfh-cell perturbations might contribute to the relative inefficiency of HIV-infected individuals to generate broadly neutralizing antibodies (bNAbs). The present review will highlight these recent findings addressing the role of Tfh cells in HIV infection as well as the impact HIV infection has on Tfh and circulating memory Tfh (cTfh) cell frequency and function.