Central corneal thickness in Latinos
Central corneal thickness in Latinos
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DOI：
10.1167/iovs.02-0641
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发表时间：
2003-04-01
影响因子：
4.4
通讯作者：
Varma, R
中科院分区：
文献类型：
--
作者：
Hahn, S;Azen, S;Varma, R
目的。目的：探讨40岁以上拉美裔患者角膜中央厚度（CCT）的特征。来自加利福尼亚州拉普恩特两个人口普查区的拉美裔人群进行了CCT和眼压（IOP）的测量。超声测厚仪测CCT，压扁眼压仪测IOP。1699名参与者每人一只眼睛被纳入分析。平均（+/- sd） CCT为546.9 +/- 33.5 mum。与40 ~ 49岁的参与者相比，年龄较大的参与者（大于或等于70岁）的CCs明显更薄（P < 0.05）。高眼压组比正常组和青光眼组cc较厚（P < 0.05）。多变量自适应回归样条分析和IOP亚组方差对比分析显示，cc较薄的眼的IOP低于cc较厚的眼（P < 0.001）。同一受试者CCT的眼间差异绝对范围高达24 μ m。平均而言，拉美裔的有条件现金转移比之前报道的白人少，但比非洲裔美国人和亚洲人多。与年轻的拉丁美洲人相比，年长的拉丁美洲人的角膜更薄。在25 μ m或更大的CCT中，不对称应被评估为潜在的角膜疾病。样条分析表明，虽然IOP和CCT之间的关系最好用非线性方程来解释，但当用Goldmann眼压计测量IOP时，很可能低估了cc较薄的眼睛的IOP，而高估了cc较厚的眼睛的IOP。
PURPOSE. To characterize central corneal thickness (CCT) in Latinos aged 40 or more years.METHODS. A population-based cohort of Latinos from two census tracts in La Puente, California, underwent measurements of CCT and intraocular pressure (IOP). CCT was measured with an ultrasonic pachymeter, and IOP was measured by applanation tonometry. One eye of each of 1699 participants was included in the analyses.RESULTS. The mean (+/-SD) CCT was 546.9 +/- 33.5 mum. Older participants (greater than or equal to70 years) had significantly thinner CCs compared with participants 40 to 49 years of age (P < 0.05). Eyes with ocular hypertension had thicker CCs than did normal and glaucomatous eyes (P < 0.05). Multivariate adaptive regression spline analyses and analysis of variance contrasting IOP subgroups revealed that eyes with thinner CCs had lower IOP than did eyes with thicker CCs (P < 0.001). The absolute range of interocular differences in CCT in the same subject was as high as 24 mu m.CONCLUSIONS. On average, CCT in Latinos was less than that previously reported in whites but greater than that reported in African Americans and Asians. Older Latinos had thinner corneas compared with younger Latinos. Asymmetry in CCT of 25 mu m or more should be evaluated for potential corneal disease. Spline analyses suggest that although the relationship between IOP and CCT is best explained by a nonlinear equation, when measuring IOP with the Goldmann tonometer, it is likely that IOP is underestimated in eyes with thinner CCs and overestimated in eyes with thicker CCs.