Continuous cognitive improvement 1 year following successful kidney transplant
Continuous cognitive improvement 1 year following successful kidney transplant
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DOI：
10.1038/ki.2011.40
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发表时间：
2011-06-01
影响因子：
19.6
通讯作者：
Rutkowski, Boleslaw
中科院分区：
文献类型：
--
作者：
Harciarek, Michal;Biedunkiewicz, Bogdan;Rutkowski, Boleslaw
最近，成功的肾移植被证明能够改善慢性透析患者的认知能力。为了检验移植的早期认知益处是否随着患者的持续康复而持续发展，我们在一项前瞻性对照研究中解决了这些问题，研究对象包括27名随后接受肾移植的透析患者、18名等待肾移植的透析患者和30名没有肾脏疾病的匹配对照组。总体而言，成功的肾脏移植在一年后的运动/精神运动速度、视觉规划、记忆和抽象推理测试中的表现有统计上的显著改善。我们还研究了接受透析的患者的认知能力是稳定的还是随着时间的推移而下降的，发现实际上随着时间的推移，即使是充分透析的患者，认知能力也会下降。记忆功能的衡量标准受到的影响尤其大。这项研究表明，移植的早期益处不是暂时的，移植后1年仍然明显。《国际肾脏》(2011年)79,1353-1360；doi：10.1038/ki.2011.40；2011年3月9日在线发布
Successful kidney transplantation was recently shown to lead to improvement in the cognitive performance of patients on chronic dialysis. To examine whether the early cognitive benefits of transplantation continue to develop over time, along with the patients' ongoing recovery, we addressed these questions in a prospective controlled study of 27 dialyzed patients who subsequently received a kidney transplant, 18 dialyzed patients awaiting kidney transplant, and 30 matched controls without kidney disease. Overall, successful kidney transplant contributed to a statistically significant improvement in performance on tests of motor/psychomotor speed, visual planning, memory, and abstract reasoning tested 1 year later. We also studied whether the cognitive performance of patients maintained on dialysis is stable or declines over time and found that it actually declined over this time even in adequately dialyzed patients. Measures of memory functions were particularly affected. This study indicates that the early beneficial effects of transplantation are not transient and were still evident 1 year following transplantation. Kidney International (2011) 79, 1353-1360; doi:10.1038/ki.2011.40; published online 9 March 2011