Health-related quality of life in active injecting drug users with and without chronic hepatitis C virus infection
Health-related quality of life in active injecting drug users with and without chronic hepatitis C virus infection
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DOI：
10.1002/hep.20014
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发表时间：
2004-01-01
期刊：
影响因子：
13.5
通讯作者：
Steen, T
中科院分区：
文献类型：
--
作者：
Dalgard, A;Egeland, A;Steen, T
本研究评估了慢性丙型肝炎病毒（HCV）感染对注射吸毒者健康相关生活质量（HRQOL）的影响，比较了注射吸毒者与非慢性HCV感染者的HRQOL。这项研究包括199名18岁以上的注射毒品使用者，他们参加了针头交换计划。用聚合酶链反应方法检测血清中HCV RNA的存在。使用SF-36问卷测量HRQOL，测量过去4周的HRQOL。HCV RNA检测阳性102例（51%），阴性97例（49%）。积极注射毒品使用者的HRQOL评分显着降低相比，人口标准。然而，我们没有发现较差的HRQOL在注射吸毒者慢性HCV感染者比注射吸毒者没有HCV感染。在SF-36 8个维度中的4个维度（一般健康、身体功能、身体角色和活力）中，知晓感染的HCV RNA阳性注射吸毒者的HRQOL评分低于未知晓感染者。HCVRNA阴性的受试者，谁相信他们被感染，得分更差的一个维度（一般健康）相比，那些谁不相信他们被感染。总之，慢性HCV感染本身并没有负面影响的HRQOL的积极注射吸毒者。那些认为自己被感染的人的HRQOL评分低于那些认为自己没有被感染的人。
This study assessed the effect of chronic hepatitis C virus (HCV) infection on the health-related quality of life (HRQOL) of injecting drug users, comparing the HRQOL of injecting drug users with and without chronic HCV infection. The study included 199 injecting drug users of more than 18 years of age who participated in a needle exchange program. Blood samples were tested for the presence of HCV RNA in serum with a polymerase chain reaction method. HRQOL was measured using the questionnaire SF-36, measuring HRQOL over the last 4 wk. The HCV RNA test was positive in 102 (51%) and negative in 97 (49%) subjects. The HRQOL scores of actively injecting drug users were markedly reduced compared to the population norm. However, we did not find poorer HRQOL in injecting drug users with chronic HCV infection than in injecting drug users without HCV infection. HCV RNA positive injecting drug users who were aware of the infection had lower HRQOL scores than those unaware of the infection in 4 of the 8 SF-36 dimensions (general health, physical functioning, physical role, and vitality). HCVRNA negative subjects, who believed they were infected, scored worse in one dimension (general health) compared to those who did not believe they were infected. In conclusion, chronic HCV infection per se did not negatively affect the HRQOL of active injecting drug users. Those who thought they were infected had a lower HRQOL scores than those who believed they were not infected.