Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil.
Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil.
复制标题
DOI：
10.1111/ahg.12047
复制
发表时间：
2014-01
影响因子：
1.9
通讯作者：
Velasquez-Melendez G
中科院分区：
文献类型：
--
作者：
Pena GG;Dutra MS;Gazzinelli A;Corrêa-Oliveira R;Velasquez-Melendez G
To estimate the heritability and genetic correlation between glucose homeostasis and adiposity traits in a population in a rural community in Brazil. The Jequitinhonha Community Family Study cohort consists of subjects aged ≥ 18 years residing in rural areas in Brazil. The data on the following traits were assembled for 280 individuals (51.7% women): body mass index, body fat percentage, waist and mid-upper arm circumferences, triceps skinfold, conicity index, insulin, glucose, high-density lipoprotein cholesterol, triglycerides and C-reactive protein. Extended pedigrees were constructed up to the third generation of individuals using the data management software PEDSYS. The heritability and genetic correlations were estimated using a variance component method. The age- and sex-adjusted heritability values estimated for insulin (h2=52%), glucose (h2=51%), high-density lipoprotein (HDLc; h2=58%), and waist circumference (WC; h2=49%) were high. Significantly adjusted genetic correlations were observed between insulin with body mass index (BMI;ρg=0.48), WC (ρg=0.47) and HDLc (ρg= −0.47). The homeostasis model assessment of insulin resistance (HOMA-IR) was genetically correlated with BMI (ρg=0.53) and HDLc (ρg=−0.58). The adjusted genetic correlations between traits were consistently higher compared with the environmental correlations. Glucose metabolism and adiposity traits are highly heritable and share common genetic effects with body adiposity traits.
登录
查看更多内容
DOI：
10.1161/01.atv.13.5.687
发表时间：
1993-05-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
AUSTIN, MA;NEWMAN, B;KRAUSS, RM
通讯作者：
KRAUSS, RM
影响因子：
6.4
作者：
Dutra, Miriam S.;Bela, Samantha R.;Gazzinelli, Ricardo T.
通讯作者：
Gazzinelli, Ricardo T.
DOI：
10.4103/0971-6866.64944
发表时间：
2010-01-01
期刊：
Indian journal of human genetics
影响因子：
--
作者：
Ghosh, Arnab;Dutta, Rupak;Sarkar, Angshuman
通讯作者：
Sarkar, Angshuman
影响因子：
9.8
作者：
Godsland, Ian F.;Lecamwasam, Kamalini;Johnston, Desmond G.
通讯作者：
Johnston, Desmond G.
影响因子：
158.5
作者：
HAFFNER, SM;STERN, MP;PATTERSON, JK
通讯作者：
PATTERSON, JK