Central Centrifugal Cicatricial Alopecia What Has Been Achieved, Current Clues for Future Research
Central Centrifugal Cicatricial Alopecia What Has Been Achieved, Current Clues for Future Research
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DOI：
10.1016/j.det.2013.12.005
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发表时间：
2014-04-01
影响因子：
2.4
通讯作者：
Olsen, Elise A.
中科院分区：
文献类型：
--
作者：
Ogunleye, Temitayo A.;McMichael, Amy;Olsen, Elise A.
中央离心性疤痕性脱发是一种炎症型中央头皮脱发，主要见于非洲裔女性。患病率未知，但可能在 2.7% 至 5.7% 之间变化，并随着年龄的增长而增加。这篇综述概述了历史和当前的信念，并为未来研究这一神秘疾病确定了线索。尽管中央离心性瘢痕性脱发的原因尚不清楚，但研究仍在进行中。细胞角蛋白、雄激素、遗传学和各种可能的慢性炎症来源在疾病发病机制中的作用仍有待阐明。
Central centrifugal cicatricial alopecia is an inflammatory type of central scalp hair loss seen primarily in women of African descent. The prevalence is unknown, but may vary from 2.7% to 5.7% and increases with age. This review outlines the history and current beliefs and identifies clues for future research for this enigmatic condition. Despite that the cause of central centrifugal cicatricial alopecia is unknown, research is ongoing. The role of cytokeratins, androgens, genetics, and various possible sources of chronic inflammation in disease pathogenesis remain to be elucidated.