VMN LESION DEFICITS IN LORDOSIS - PARTIAL REVERSAL WITH PERGOLIDE MESYLATE
VMN LESION DEFICITS IN LORDOSIS - PARTIAL REVERSAL WITH PERGOLIDE MESYLATE
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DOI：
10.1016/0031-9384(83)90269-x
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发表时间：
1983-01-01
影响因子：
2.9
通讯作者：
HOLLINGSWORTH, EM
中科院分区：
文献类型：
--
作者：
MATHEWS, D;GREENE, SB;HOLLINGSWORTH, EM
双侧VMN（下丘脑腹内侧核）的损伤实际上消除了雌激素-孕激素刺激的去势雌性大鼠的脊柱前凸。甲磺酸培高利特（一种强效长效多巴胺受体激动剂）治疗后，脊柱前凸可能会有所恢复。甲磺酸培高利特联合雌激素和孕激素长期给药导致VMN损伤雌性大鼠的脊柱前凸显著恢复。恢复程度与培高利特的持续时间和/或剂量相关。
Bilateral lesions of the VMN [ventromedial nucleus of the hypothalamus] virtually eliminate estrogen-progesterone stimulated lordosis in the spayed female rat. Some recovery in lordosis is possible following treatment with pergolide mesylate, a potent long acting dopamine agonist. Chronic administration of pergolide mesylate in combination with estrogen and progesterone resulted in significant recovery of lordosis in VMN lesioned female rats. The magnitude of recovery was related to the duration and/or dose of pergolide.