Mesenchymal Stem Cell Therapy: Hope for Patients With Systemic Lupus Erythematosus.
Mesenchymal Stem Cell Therapy: Hope for Patients With Systemic Lupus Erythematosus.
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DOI：
10.3389/fimmu.2021.728190
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发表时间：
2021
影响因子：
7.3
通讯作者：
Pan Q
中科院分区：
文献类型：
--
作者：
Li A;Guo F;Pan Q;Chen S;Chen J;Liu HF;Pan Q
系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病。虽然以往的研究已经证明SLE与免疫系统中细胞的失衡有关，包括B细胞、T细胞和树突状细胞等，SLE发病的机制尚不清楚。因此，目前尚缺乏有效、低副作用的SLE治疗方法。近年来，间充质干细胞（MSC）治疗自身免疫性疾病，特别是系统性红斑狼疮，已获得越来越多的关注。该疗法可通过促进Th2和Treg细胞的增殖，抑制Th1、Th17和B细胞等的活性来改善难治性SLE的体征和症状。然而，也有报道称MSC疗法在某些SLE患者中无效，这可能与MSC或患者源性因子有关。因此，骨髓间充质干细胞的治疗作用有待进一步证实。本文从三个方面综述了MSC治疗难治性SLE的现状以及MSC治疗无效的潜在原因。我们提出了多种MSC修饰方法，这些方法可能有益于增强SLE中MSC的免疫抑制作用。但其对SLE患者的安全性和保护作用仍需进一步的实验和临床证据证实。
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Although previous studies have demonstrated that SLE is related to the imbalance of cells in the immune system, including B cells, T cells, and dendritic cells, etc., the mechanisms underlying SLE pathogenesis remain unclear. Therefore, effective and low side-effect therapies for SLE are lacking. Recently, mesenchymal stem cell (MSC) therapy for autoimmune diseases, particularly SLE, has gained increasing attention. This therapy can improve the signs and symptoms of refractory SLE by promoting the proliferation of Th2 and Treg cells and inhibiting the activity of Th1, Th17, and B cells, etc. However, MSC therapy is also reported ineffective in some patients with SLE, which may be related to MSC- or patient-derived factors. Therefore, the therapeutic effects of MSCs should be further confirmed. This review summarizes the status of MSC therapy in refractory SLE treatment and potential reasons for the ineffectiveness of MSC therapy from three perspectives. We propose various MSC modification methods that may be beneficial in enhancing the immunosuppression of MSCs in SLE. However, their safety and protective effects in patients with SLE still need to be confirmed by further experimental and clinical evidence.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
TNF-α通过NF-κB途径促进MSC在氧化应激下的存活和迁移，以减轻静脉移植物中内膜增生的衰减。
影响因子：
5.3
作者：
Bai X;Xi J;Bi Y;Zhao X;Bing W;Meng X;Liu Y;Zhu Z;Song G
通讯作者：
Song G
DOI：
10.1038/nrrheum.2010.176
发表时间：
2010-12
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6
作者：
Baer, Patrick C.;Sann, Julia;Schubert, Ralf
通讯作者：
Schubert, Ralf
DOI：
10.1002/stem.2509
发表时间：
2017-03
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Davies LC;Heldring N;Kadri N;Le Blanc K
通讯作者：
Le Blanc K