Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation
Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation
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DOI：
10.1016/j.ejpb.2009.06.014
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Cameron, R. E.
中科院分区：
文献类型：
--
作者：
Laity, P. R.;Mantle, M. D.;Cameron, R. E.
两种方法用于调查片剂溶胀的能力进行了研究，基于模型凝胶形成系统的研究。从磁共振成像（MRI）的结果进行了比较，从一个新的应用程序的X射线显微断层扫描（X μ T）跟踪嵌入的玻璃微球示踪剂的模型片剂膨胀的运动的结果。MRI提供了关于水合前沿进入片剂的运动和溶胀凝胶层的组成的信息，溶胀凝胶层在片剂表面形成并随时间推移逐渐增厚。相反，X mu T显示在短时间内和水合前沿之前片芯内的显著轴向膨胀，其中通过MRI观察到的水不足（对于此处使用的系统估计为约15重量%）。因此，MRI和X μ T可被视为研究片剂的水合和溶胀行为的补充方法。(C)2009爱思唯尔有限公司版权所有。
The capabilities of two methods for investigating tablet swelling are investigated, based on a study of a model gel-forming system. Results from magnetic resonance imaging (MRI) were compared with results from a novel application of X-ray microtomography (X mu T) to track the movements of embedded glass microsphere tracers as the model tablets swelled. MRI provided information concerning the movement of hydration fronts into the tablets and the composition of the swollen gel layer, which formed at the tablet surface and progressively thickened with time. Conversely, X mu T revealed significant axial expansion within the tablet core, at short times and ahead of the hydration fronts, where there was insufficient water to be observed by MRI (estimated to be around 15% by weight for the system used here). Thus, MRI and X mu T may be regarded as complementary methods for studying the hydration and swelling behaviour of tablets. (C) 2009 Elsevier B.V. All rights reserved.