Direct diffusion-based parcellation of the human thalamus
Direct diffusion-based parcellation of the human thalamus
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DOI：
10.1007/s00429-014-0748-2
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发表时间：
2015-05-01
影响因子：
3.1
通讯作者：
Grodd, Wolfgang
中科院分区：
文献类型：
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作者：
Kumar, Vinod;Mang, Sarah;Grodd, Wolfgang
为了评估人类丘脑的稳定解剖特征，采用无偏扩散张量分割方法对具有相似空间取向的丘脑亚结构进行分割。我们确定了63名健康受试者（32名男性/31名女性）中21个丘脑簇的定位、大小和个体差异。侧性差异占丘脑体积的+/- 6%，性别差异占丘脑体积的+/- 4%。依次在丘脑前部、内侧、外侧和后部选择5个稳定的簇，这些簇为90%的受试者所共有，且至少包含10个体素。这些簇可分为前腹侧核（AN）组，中背侧核（MD）组，内侧pulvinar （PuM）组和外侧核组。这些神经簇的皮层下和皮层连通性表明：(1) AN簇的斜向颅尾定向纤维主要连接边缘结构，(2)MD的大量背额定向纤维主要投射到前额叶皮层和内侧颞叶，(3)与x轴平行的PuM纤维投射到枕中区和颞中区，将视觉区与海马和杏仁核连接起来，并通过丘脑内通路与中额区连接起来。(4)位于运动丘脑前部和感觉丘脑后部的两个侧簇的斜尾颅纤维将来自脑干的感觉-运动信息通过内囊传递到皮层的中央前和中央周围区域。
To assess stable anatomical features of the human thalamus, an unbiased diffusion tensor parcellation approach was used to segment thalamic substructures with similar spatial orientation. We determined localization, size and individual variations of 21 thalamic clusters in a group of 63 healthy human subjects (32 males/31 females). The laterality differences accounted for +/- 6 % and gender differences for +/- 4 % of the thalamic volume. Consecutively, five stable clusters in the anterior, medial, lateral and posterior thalamus were selected, which were common to 90 % of all subjects and contained at least 10 voxels. These clusters could be assigned to the anteroventral nucleus (AN) group, the mediodorsal (MD) nucleus, the medial pulvinar (PuM), and the lateral nuclei group. The subcortical and cortical connectivity of these clusters revealed that: (1) the oblique cranio-caudal-oriented fibers of the AN cluster mainly connect to limbic structures, (2) the numerous dorso-frontal-oriented fibers of MD mainly project to the prefrontal cortex and the medial temporal lobe, (3) the fibers of the PuM running in parallel with the x-axis project to medio-occipital and medio-temporal areas and connect visual areas with the hippocampus and amygdala and via intrathalamic pathways with medio-frontal areas, and (4) the oblique caudo-cranial fibers of the two lateral clusters located anteriorly in the motor and posteriorly in the sensory thalamus are routing sensory-motor information from the brain stem via the internal capsule to pre- and peri-central regions of the cortex.