Blood pressure is related to placental volume and birth weight.
Blood pressure is related to placental volume and birth weight.
复制标题
血压与胎盘体积和出生体重有关。
作者：
M. Thame;C. Osmond;R. Wilks;F. Bennett;N. McFarlane‐Anderson;T. Forrester
这项研究的目的是确定孕妇营养与胎儿和胎盘大小是否影响血压。进行了一项纵向研究，将第一次产前探视的母亲人体测量、胎盘和胎儿大小的超声数据、出生时的人体测量以及儿童生长和血压联系起来。受试者是在牙买加金斯敦西印度群岛大学医院产前诊所就诊的428名妇女和她们的孩子，随后对她们进行了跟踪调查。1岁、2岁、2.5岁、3岁和3.5岁的收缩压是主要的测量结果。合并不同年龄的数据，出生体重每增加1公斤，收缩压下降1.4毫米汞(95%可信区间0.2至2.7，P=0.02)，胎盘体积每增加100毫升，妊娠20周时血压下降1.2毫米汞(95%可信区间0.4至2.0P=0.004)。血压与17周时胎盘体积和20周时胎儿腹围呈负相关。母亲营养状况的衡量标准与出生体重和胎盘体积密切相关，但与这些年龄段的儿童血压没有直接关系。总而言之，正如之前在欧洲人中所描述的那样，在这一人群中，血压与胎儿大小有关。我们发现妊娠中期胎盘体积和腹围与儿童血压之间存在关联，这表明血压计划的启动事件发生在怀孕早期。母亲营养状况的测量与这些年龄段的儿童血压没有直接关系，但对出生体重和胎盘体积都有很强的预测作用，这表明存在间接关系。
The objective of this study was to determine whether maternal nutrition and fetal and placental size program blood pressure. A longitudinal study linking the maternal anthropometric measurements of the first antenatal visit, ultrasound data of placental and fetal size, anthropometry at birth, and childhood growth and blood pressure was performed. The subjects were 428 women who attended the antenatal clinic at the University Hospital of the West Indies, Kingston, Jamaica, and their children, who were subsequently followed up. Systolic blood pressure at ages 1, 2, 2.5, 3, and 3.5 years was the main outcome measure. Pooling the data across ages, systolic blood pressure fell by 1.4 mm Hg for every 1-kg increase in birth weight (95% CI 0.2 to 2.7, P=0.02) and by 1.2 mm Hg for every 100-mL increase in placental volume at 20 weeks of gestation (95% CI 0.4 to 2.0, P=0.004). Blood pressure was also negatively associated with placental volume at 17 weeks and fetal abdominal circumference at 20 weeks. Measures of maternal nutritional status were strongly related to birth weight and placental volume but not directly to childhood blood pressure at these young ages. In conclusion, blood pressure is associated with fetal size in this population, as previously described among Europeans. We found associations between placental volume and abdominal circumference in the second trimester and childhood blood pressure, suggesting that the initiating events of blood pressure programming occur early in pregnancy. Measures of maternal nutritional status were not directly related to childhood blood pressure at these young ages but were strong predictors of both birth weight and placental volume, suggesting an indirect relation.
影响因子：
12.7
作者：
Cooper, R;Rotimi, C;Wilks, R
通讯作者：
Wilks, R