Gardner syndrome and periampullary malignancy.
Gardner syndrome and periampullary malignancy.
复制标题
加德纳综合征和壶腹周围恶性肿瘤。
DOI：
10.1002/ajmg.1320060305
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Hall,JG
中科院分区：
文献类型：
--
作者：
Pauli,RM;Pauli,ME;Hall,JG
在一个患有结肠息肉病和Gardner综合征（骨瘤和软组织肿瘤）的典型相关表现的家族中，两名或可能四名受影响的成员发展为壶腹周围恶性肿瘤。一项综述表明，与普通人群相比，加德纳综合征患者发生壶腹周围癌的风险可能增加100至200倍。虽然某些家庭和某些个人（有其他十二指肠受累的人，男性和表现出Gardner综合征所有特征的人）可能是最易感的，但所有Gardner综合征患者都应定期进行内镜检查，以评估是否存在上消化道疾病。
In a family with colonic polyposis and the typical associated findings of Gardner syndrome (osteomas and soft‐tissue tumors), two and possibly four of the affected members developed periampullary malignancy. A review indicates that individuals with Gardner syndrome may have a 100‐ to 200‐fold increased risk of developing periampullary carcinoma when compared to the general population. While certain families and certain individuals (those with other duodenal involvement, males and those with all of the characteristics of Gardner syndrome expressed) may be most susceptible, all patients with Gardner syndrome should be periodically endoscopically evaluated for the presence of upper gastrointestinal tract disease.