Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population.
Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population.
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DOI：
10.1002/hed.23318
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Chiosea SI
中科院分区：
文献类型：
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作者：
Dogan S;Hedberg ML;Ferris RL;Rath TJ;Assaad AM;Chiosea SI
人乳头瘤病毒（HPV）在低发病率人群鼻咽癌（npc）中的意义尚不清楚。对90例鼻咽癌患者（1957-2012年）进行eb病毒（EBV）检测。临床数据、EBV、HPV和p16状态与总生存率相关（OS； 63例；年，1981-2012）。在9例hpv阳性病例中，3例从鼻咽外部位延伸。6例经鼻咽源确诊。hpv阳性鼻咽癌的OS与ebv阳性鼻咽癌相似（85个月vs 141个月；p < 0.05）。EBV/ hpv阴性鼻咽癌患者的OS较差（34个月；p = 0.004）。非角化组织学比角化预后更好（115个月vs 25个月；p = 0.001）。在过去的几十年里，角化鼻咽癌的比例从34.5%下降到14.3% （p = 0.026）。HPV在鼻咽癌中的病因学作用已得到证实。HPV阳性对预后的有利意义与EBV阳性相似。
The significance of human papillomavirus (HPV) in nasopharyngeal carcinomas (NPCs) in a low-incidence population remains unknown. Samples from 90 patients with NPC (years, 1957–2012) were analyzed for Epstein–Barr virus (EBV). Clinical data, EBV, HPV, and p16 status were correlated with overall survival (OS; 63 cases; years, 1981–2012). Of 9 HPV-positive cases, 3 extended from extra-nasopharyngeal sites. Nasopharyngeal origin was confirmed in 6 cases. HPV-positive NPC had OS similar to EBV-positive NPC (85 vs 141 months; p > .05). The OS of patients with EBV/HPV-negative NPC was worse (34 months; p = .004). Nonkeratinizing histology was associated with better outcome than keratinizing (115 vs 25 months; p = .001). Over the last several decades, the proportion of keratinizing NPC decreased from 34.5% to 14.3% (p = .026). The etiologic role of HPV in NPC is confirmed. The favorable prognostic significance of HPV positivity is similar to that of EBV positivity.