The acquisition of passive immunity in the new-born piglet
The acquisition of passive immunity in the new-born piglet
复制标题
DOI：
10.1016/s0301-6226(02)00182-3
复制
发表时间：
2002-11-28
期刊：
影响因子：
--
通讯作者：
Bland, IM
中科院分区：
文献类型：
--
作者：
Rooke, JA;Bland, IM
由于猪胎盘的上皮细胞特性，新生的仔猪必须从摄入的初乳和牛奶中获得母体免疫球蛋白，以进行被动免疫保护，直到仔猪的免疫系统完全发育。仔猪血浆中的免疫球蛋白浓度取决于摄入的初乳量、初乳中的免疫球蛋白浓度和关闭肠道的时间(当完整的免疫球蛋白不再被仔猪的胃肠道吸收时)。关于仔猪对免疫球蛋白的吸收以及肠道关闭的机制和时机的许多可用信息都来自于对人工喂养仔猪的研究。现在人们认识到，除了生命最初24小时内初乳中免疫球蛋白浓度的变化外，初乳中还含有许多生物活性化合物，它们的浓度在生命的前24小时内也会迅速变化。现代母猪预计将饲养更多生理上不太成熟的小猪，生产者面临减少抗生素使用的压力。因此，仔猪吸收足够量的免疫球蛋白以预防疾病至关重要。本文对现代基因型自然哺乳仔猪的母体免疫球蛋白供应和仔猪对免疫球蛋白的吸收进行了评价。讨论了影响仔猪获得免疫球蛋白的营养因素和其他因素，以及被动免疫获得和主动免疫发展之间的关系。(C)2002 Elsevier Science B.V.保留所有权利。
Because of the epitheliochorial nature of the porcine placenta, the new-born piglet must acquire maternal immunoglobulins from ingested colostrum and milk for passive immune protection until the immune system of the piglet becomes fully developed. Concentrations of IgG in piglet plasma depend on the amount of colostrum ingested, IgG concentrations in colostrum and the timing of gut closure (when intact IgG can no longer be absorbed by the gastro-intestinal tract of the piglet). Much of the available information concerning IgG absorption by the piglet and the mechanism and timing of gut closure has been derived from studies using artificially-fed piglets. It is now recognised that, in addition to changes in colostrum IgG concentrations in the first 24 h of life, colostrum contains many bio-active compounds whose concentrations also change rapidly in the first 24 h of life. Modem sows are expected to rear increased numbers of physiologically less mature piglets and producers are faced with pressures to reduce antibiotic usage. Therefore it is critical that piglets absorb adequate amounts of IgG for disease protection. The review assesses the maternal supply of IgG and piglet absorption of IgG in naturally suckling piglets of modem genotype. Nutritional and other factors which may influence acquisition of IgG by the piglet are discussed and relationships between acquisition of passive immunity and development of active immunity addressed. (C) 2002 Elsevier Science B.V. All rights reserved.