PLANNING PATIENT RECRUITMENT - FANTASY AND REALITY
PLANNING PATIENT RECRUITMENT - FANTASY AND REALITY
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DOI：
10.1002/sim.4780030425
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发表时间：
1984-01-01
影响因子：
2
通讯作者：
KLETT, CJ
中科院分区：
文献类型：
--
作者：
COLLINS, JF;WILLIFORD, WO;KLETT, CJ
一个设计良好的临床试验的目标是果断地回答临床问题，并尽可能便宜。在需要大量时间、精力和资金的多中心研究中，成本考虑尤为重要。本文讨论了试验设计的两个方面：（1）确定所需的样本量和（2）确定参与者招募足够数量患者的能力。最后，我们讨论了如果研究期间出现招募问题时可能使用的一些策略。
The goal of a well designed clinical trial is to answer clinical questions decisively and as inexpensively as possible. Cost considerations are particularly important in multicentre studies which require substantial time, effort and funding. This paper discusses two aspects of designing trials:(1) determination of required sample size and (2) determination of the participants’ ability to recruit a sufficient number of patients. Finally, we address some possible strategies to use if a recruitment problem arises during the study.