Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats
Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats
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DOI：
10.1007/s11605-008-0678-5
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发表时间：
2009-02-01
影响因子：
3.2
通讯作者：
Gundogdu, Haldun
中科院分区：
文献类型：
--
作者：
Ersoy, Eren;Ozturk, Vedat;Gundogdu, Haldun
本研究的目的是在动物模型中评估两种可吸收膜屏障（聚乳酸和透明质酸钠-羧甲基纤维素钠）在预防术后腹腔粘连、炎症和纤维化方面的功效。 将 40 只 Wistar 白化大鼠分为聚乳酸、透明质酸钠-羧甲基纤维素和对照组。所有大鼠均接受剖腹手术，随后进行盲肠壁磨损和腹壁损伤。两个治疗组接受聚乳酸或透明质酸钠-羧甲基纤维素膜屏障，而对照组则不接受任何治疗。术后第 21 天，三名观察者对腹内粘连进行分级并切除标本。使用定量评分系统对纤维化、炎症和粘连进行分级。与对照组相比，聚乳酸组的炎症和粘连明显减少（p < 0.005），而纤维化则没有显着差异。透明质酸钠-羧甲基纤维素组的粘连明显减少（p < 0.005），但与对照组相比，纤维化和炎症没有显着差异。聚乳酸组和透明质酸钠-羧甲基纤维素组在粘连形成、炎症或纤维化方面没有显着差异。在受伤表面之间放置聚乳酸或透明质酸钠-羧甲基纤维素膜屏障与术后粘连率显着降低相关。两个障碍之间没有发现任何优势。
The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate-carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model.Forty Wistar albino rats were grouped as polylactic acid, sodium hyaluronate-carboxymethyl cellulose, and control. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The two treatment groups received polylactic acid or sodium hyaluronate-carboxymethyl cellulose film barriers, while control group received nothing. On postoperative day 21, three observers graded the intra-abdominal adhesions and resected specimens. Fibrosis, inflammation, and adhesions were graded using quantitative scoring systems.When compared to control group, polylactic acid group showed significantly less inflammation and adhesion (p < 0.005), while there was no significant difference for fibrosis. Sodium hyaluronate-carboxymethyl cellulose group has showed significantly less adhesions (p < 0.005), but there were no significant differences among fibrosis and inflammation when compared to control group. There were no significant differences between polylactic acid and sodium hyaluronate-carboxymethyl cellulose groups on adhesion formation, inflammation, or fibrosis.Placement of polylactic acid or sodium hyaluronate-carboxymethyl cellulose film barriers between injured surfaces is associated with a significantly reduced rate of postoperative adhesions. No superiority was detected between two barriers.