Difference in accumulation of puffer fish toxin and crystalline tetrodotoxin in the puffer fish,Fugu rubripes rubripes.
Difference in accumulation of puffer fish toxin and crystalline tetrodotoxin in the puffer fish,Fugu rubripes rubripes.
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河豚、红鳍东方鲀体内河豚毒素和结晶河鲀毒素积累的差异。
DOI：
10.2331/suisan.47.535
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发表时间：
1981
影响因子：
0.4
通讯作者：
S. Konosu
中科院分区：
文献类型：
--
作者：
T. Matsui;S. Hamada;S. Konosu
为了检测无公害养殖河豚是否能蓄积口服河豚毒素(TTX)，对河豚有毒卵巢、河豚甲醇提取物和河豚晶体毒素进行了为期20天的饲养试验，并对各组织进行了毒性生物测定。投喂卵巢组在第5天所有受试组织均已中毒，且在实验期间大部分组织的毒性逐渐增加。甲醇提取液组在第5天仅肝、皮、脾、胆出现中毒，20天后其他组织也出现中毒。但本组大部分样品的毒性均明显低于卵巢喂养组的相应样品。与上述两组形成鲜明对比的是，在整个实验期间，TTX饲喂组在所有组织中几乎没有显示任何毒性。
In order to examine whether the innocuous cultured puffer fish, Fugu rubripes rubripes (Japanese name, torafugu), is able to accumulate orally administered tetrodotoxin (TTx) or not, a feeding test was carried out for 20 days using the toxic ovary of puffer fish, its methanol extract, and crystalline TTx, and the toxicity of various tissues was bioassayed. In the fish of the ovary-feeding group, all the tissues tested were already toxic on the 5th day, and the toxicity of most tissues increased gradually during the experimental period. In the fish of the methanol extract-feeding group, only the liver, skin, spleen, and gall-bladder were toxic on the 5th day, and the other tissues also became toxic after 20 days. However, the toxicity of most samples of this group were remarkably lower than those of the corresponding samples of the ovary-feeding group. In a striking contrast to the above two groups, the TTx-feeding group showed almost no toxicity in all the tissues throughout the experimental period.