Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration
Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration
复制标题
DOI：
10.1073/pnas.042671399
复制
发表时间：
2002-02-19
影响因子：
11.1
通讯作者：
Mitchell, JB
中科院分区：
文献类型：
--
作者：
Krishna, MC;English, S;Mitchell, JB
描述了一种使用低场磁共振扫描仪和顺磁造影剂进行肿瘤氧合活体成像的有效方法。该方法基于Overhauser增强磁共振成像(OMRI)，这是一种功能成像技术。在荷瘤小鼠(鳞状细胞癌)上进行OMRI实验。给予造影剂Oxo63(一种高度衍生化的三芳基甲基自由基)，无毒剂量范围为2-7 mmol/kg，作为团注或持续输注。来自荷瘤小鼠的OMRI实验的空间分辨率Po(2)(氧浓度)图像显示出不同的氧合曲线，并揭示了肿瘤中的缺氧区(
An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2-7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO(2) (oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (