Case Report: Sclerosing Orbital Inflammation Caused by Leishmania braziliensis
Case Report: Sclerosing Orbital Inflammation Caused by Leishmania braziliensis
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DOI：
10.4269/ajtmh.16-0389
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发表时间：
2017-01-01
影响因子：
3.3
通讯作者：
Cruz, Angela Kaysel
中科院分区：
文献类型：
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作者：
Cruz, Antonio Augusto V.;Alves-Ferreira, Eliza V. C.;Cruz, Angela Kaysel
非特异性眼眶炎症（通常称为“眼眶假瘤”）的眼眶活检通常显示多克隆淋巴细胞、浆细胞、白细胞、巨噬细胞和不同程度的胶原沉积的组合。在此，我们报告了一位有皮肤粘膜利什曼病阳性病史的患者，他的眼眶肿块具有特发性眼眶炎症的组织学特征。眼眶标本的免疫组织化学和分子分析表明，眼眶炎症与巴西利什曼原虫抗原和疟原虫DNA的存在有关。
Orbital biopsy of nonspecific orbital inflammation, commonly referred to as "orbital pseudotumor," typically shows a combination of polyclonal lymphocytes, plasmocytes, leukocytes, macrophages, and variable degrees of collagen deposition. Herein, we report a patient with a positive history of mucocutaneous leishmaniasis who presented with an orbital mass with a histological profile of idiopathic orbital inflammation. Immunohistochemical and molecular analysis of the orbital specimens demonstrated that the orbital inflammation was associated with the presence of antigens of Leishmania braziliensis and DNA from the parasite.