Impaired Endothelial Function in Patients With Postural Tachycardia Syndrome.
Impaired Endothelial Function in Patients With Postural Tachycardia Syndrome.
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DOI：
10.1161/hypertensionaha.120.16238
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发表时间：
2021-03-03
期刊：
影响因子：
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通讯作者：
Gamboa A
中科院分区：
文献类型：
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作者：
Chopoorian AH;Wahba A;Celedonio J;Nwazue V;Smith EC;Garland EM;Paranjape S;Okamoto LE;Black BK;Biaggioni I;Raj SR;Gamboa A
The purpose of this study is to evaluate endothelial function in postural tachycardia syndrome (PoTS), a poorly understood chronic condition characterized by a state of consistent orthostatic tachycardia (delta heart rate ≥30 beats per minute) upon standing without orthostatic hypotension. Nineteen PoTS patients and nine healthy controls were studied after 3 days of a fixed, caffeine-free, normal sodium (150 milliequivalents/day) diet. All participants underwent autonomic function testing including sinus arrhythmia, Valsalva maneuver, hyperventilation, cold pressor, handgrip, and a standing test with catecholamine measurements, followed by endothelial function testing. We analyzed three measures of endothelial function: percent brachial flow mediated dilation (FMD), Digital Pulsatile Arterial Tonometry (EndoPAT), and post-ischemic percent leg blood flow (%LBF). FMD was significantly lower in PoTS patients (6.23 ± 3.54 % for PoTS) than in healthy controls (10.6 ± 4.37 % for Controls vs, p=0.014). PoTS and Controls had similar EndoPAT (1.93 ± 0.40 Arbitrary Units for Controls vs 2.13 ± 0.63 Arbitrary Units for PoTS). PoTS had similar, but suggestive %LBF to Controls (313 ± 158 % for PoTS vs 468 ± 236 % for Controls, p=0.098). Patients with PoTS have significantly reduced FMD compared to healthy controls, suggesting that PoTS is characterized by endothelial dysfunction in conduit arteries.
