Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma
Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma
复制标题
国际肿瘤出芽共识会议（2016）对口腔舌鳞状细胞癌建议的验证。
DOI：
10.1111/jop.12856
复制
发表时间：
2019-07-01
影响因子：
3.3
通讯作者：
Wang, Cheng
中科院分区：
文献类型：
--
作者：
Xie, Nan;Yu, Pei;Wang, Cheng
背景
肿瘤出芽是口腔舌鳞状细胞癌（OTSCC）的一个有价值的预后指标，但缺乏一个标准化的评分系统。本研究的目的是根据2016年国际肿瘤出芽共识会议（ITBCC）推荐的评分系统，评估OTSCC患者肿瘤出芽的预后价值。
方法
在255例OTSCC患者中，按照ITBCC的建议对肿瘤出芽进行评分。然后，肿瘤出芽和临床病理参数之间的关联进行了研究。其中136例有随访资料的患者采用Kaplan-Meier法评价总生存期。采用考克斯回归分析评估肿瘤出芽的预后价值。通过kappa统计计算观察者间和观察者内一致性。
结果
肿瘤出芽评分与OTSCC患者的淋巴结转移、分化、浸润模式、淋巴浸润、肿瘤复发、浸润深度和OS降低相关。考克斯分析显示，高出芽评分是所有临床分期和临床早期OTSCC患者的独立预后因素。观察者内和观察者间均获得了较高的Kappa值。
结论
国际肿瘤出芽共识评分系统是一种简单、可靠、可重复的测量OTSCC肿瘤出芽的方法，应包括在常规病理报告中。
BACKGROUND
Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study was to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.
METHODS
Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow-up data available were used to evaluate overall survival (OS) by the Kaplan-Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter-observer and intra-observer agreement was calculated by the kappa statistic.
RESULTS
Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced OS in OTSCC patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early-stage OTSCC. The high kappa values were achieved in intra-observer and inter-observer.
CONCLUSIONS
International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in OTSCC, which should be included in the routine pathological report.