Discovery of unexpectedly complex reaction pathways for the Knorr pyrazole synthesis via transient flow
Discovery of unexpectedly complex reaction pathways for the Knorr pyrazole synthesis via transient flow
复制标题
发现通过瞬态流合成克诺尔吡唑的出乎意料的复杂反应途径
DOI：
10.1039/d2re00271j
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发表时间：
2023
影响因子：
3.9
通讯作者：
Schrecker L
中科院分区：
文献类型：
--
作者：
Schrecker L
采用瞬态流动法获得了苯肼与1，3-二酮反应（Knorr吡唑合成）的动力学数据。在进一步的光谱和质谱数据的支持下，随后构建了一个微观动力学模型，该模型为该机制提供了新的见解，包括自催化和意外反应中间体的参与。在这项工作中，一种新的反应物化学计量瞬态流动方法进行了论证，使这些模型的鲁棒性被断言。
Kinetic data for reactions between phenyl hydrazine and 1,3-diketones (Knorr pyrazole synthesis) were acquired by using transient flow methods. Supported by further spectroscopic and mass spectrometry data, a microkinetic model was subsequently constructed, which provided new insights into the mechanism, including autocatalysis and the involvement of an unexpected reaction intermediate. During this work, a novel reactant stoichiometry transient flow methodology was demonstrated, allowing the robustness of these models to be asserted.