A NOVEL CYTOARCHITECTONIC AREA INDUCED EXPERIMENTALLY WITHIN THE PRIMATE VISUAL-CORTEX
A NOVEL CYTOARCHITECTONIC AREA INDUCED EXPERIMENTALLY WITHIN THE PRIMATE VISUAL-CORTEX
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DOI：
10.1073/pnas.88.6.2083
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发表时间：
1991-03-01
影响因子：
11.1
通讯作者：
WILLIAMS, RW
中科院分区：
文献类型：
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作者：
RAKIC, P;SUNER, I;WILLIAMS, RW
大脑皮层可分为许多细胞结构区，但调节其数量和大小的发育机制尚不清楚。在这里，我们提供的证据表明，在妊娠中期，减少投射到初级视觉皮层（17区）的选定丘脑纤维的数量，会诱导形成一个新的细胞结构区域，该区域位于17区的边界并嵌入其中。这个区域被称为X区，在细胞结构上不同于17区和相邻的次级视觉皮层（18区）。我们认为，丘脑和皮层连接的异常组合作用于被剥夺正常丘脑输入的前瞻区17，可能导致混合皮层的形成。我们的研究结果支持皮层包裹的原图假说，并表明在进化过程中，依赖于皮层神经元和传入纤维固有特性的独特组合的细胞间相互作用可能产生新的细胞结构区域。
The cerebral cortex is divisible into a number of cytoarchitectonic areas, but developmental mechanisms that regulate their number and size remain unknown. Here we provide evidence that reducing the population of selected thalamic fibers projecting into the primary visual cortex (area 17) of monkeys during midgestation induces the formation of a novel cytoarchitectonic area situated along the border of and embedded within area 17. This region, termed area X, differs cytoarchitectonically from both area 17 and the adjacent secondary visual cortex (area 18). We propose that an aberrant combination of thalamic and cortical connections acting on a portion of prospective area 17 deprived of its normal thalamic input may result in formation of a hybrid cortex. Our results support the protomap hypothesis of cortical parcellation and suggest how during evolution new cytoarchitectonic regions may arise by cell-cell interactions that depend on a unique combination of intrinsic properties of cortical neurons and afferent fibers.