GROWTH INHIBITION OF ESCHERICHIA-COLI BY NEW THYMIDINE ANALOGS
GROWTH INHIBITION OF ESCHERICHIA-COLI BY NEW THYMIDINE ANALOGS
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DOI：
10.1021/ja01608a053
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发表时间：
1955-01-01
影响因子：
15
通讯作者：
VISSER, DW
中科院分区：
文献类型：
--
作者：
BELTZ, RE;VISSER, DW
描述了 3-甲基胸苷、5-羟基脱氧尿苷和 5-溴-脱氧尿苷的制备以及脱氧胞苷脱氨基的改进方法。 5-羟基脱氧尿苷显示在18小时时以20μg/ml的水平完全抑制大肠杆菌K-12的生长。 5-溴脱氧尿苷的效果约为1/30，而3-甲基胸苷、胸苷、脱氧胞苷和脱氧尿苷则不产生抑制作用。令人感兴趣的是，5-取代的脱氧核糖基嘧啶是唯一能抑制既不需要嘌呤也不需要嘧啶化合物生长的微生物生长的取代核苷。
The preparation of 3-methylthymidine, 5-hydroxydeoxyuridine, and 5-bro-modeoxyuridine and an improved method for the deamination of deoxycytidine are described. 5-Hydroxydeoxyuridine was shown to suppress completely the growth of E. coli K-12 at 18 hours at a level of 20 [mu]g/ml. 5-Bromodeoxyuridine is about l/30th as effective, while 3-methylthymidine, thymidine, deoxycytidine and deoxyuridine produce no inhibition. It is of interest that 5-substituted deoxyribosylpyrimidines are the only substituted nucleosides which inhibit growth of microorganisms which require neither purine nor pyrimidine compounds for growth.