Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge Myrmekioderma sp.
Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge Myrmekioderma sp.
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Myrindole A，一种来自海洋海绵 Myrmekioderma sp 的抗菌双吲哚。
DOI：
10.1021/acs.orglett.1c00922
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Matsunaga Shigeki
中科院分区：
文献类型：
--
作者：
Moosmann Philipp;Taniguchi Tohru;Furihata Kazuo;Utsumi Hiroaki;Ise Yuji;Morii Yasuhiro;Yamawaki Nobuhiro;Takatani Tomohiro;Arakawa Osamu;Okada Shigeru;Matsunaga Shigeki
Myrindole A 是一种双吲哚生物碱，从深海海绵 Myrmekiodermasp 中分离出来。该分子的高度不饱和度使其结构通过标准 2D-NMR 实验复杂化，但最终通过结合 1H–15N-HMBC 和 1,n-ADEQUATE 实验以及测量和计算的 CD 光谱的比较来实现。 Myrindole A 对革兰氏阳性菌和革兰氏阴性菌均表现出抗菌活性。
Myrindole A, a bis-indole alkaloid, was isolated from the deep-sea spongeMyrmekiodermasp. The high degree of unsaturation of the molecule complicated the assignment of its structure by standard 2D-NMR experiments but was ultimately achieved by a combination of1H–15N-HMBC and 1,n-ADEQUATE experiments as well as the comparison of measured and calculated CD spectra. Myrindole A showed antimicrobial activity against Gram-positive and Gram-negative bacteria.