Late preventive effects against carbon tetrachloride-induced liver necrosis of the calcium chelating agent Calcion.
Late preventive effects against carbon tetrachloride-induced liver necrosis of the calcium chelating agent Calcion.
复制标题
钙螯合剂Calcion对四氯化碳引起的肝坏死的后期预防作用。
DOI：
10.1007/bf00316447
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发表时间：
1989
影响因子：
6.1
通讯作者：
Castro,JA
中科院分区：
文献类型：
--
作者：
deFerreyra,EC;Villarruel,MC;Bernacchi,AS;Fernández,G;deFenos,OM;Castro,JA
在协议的假设，钙稳态的变化可能是显着的化学诱导的肝细胞损伤的后期阶段，钙螯合剂，钙，能够部分防止四氯化碳诱导的肝坏死观察到在24小时，治疗后6或10小时的肝毒素。钙对反应性代谢物与细胞成分的共价结合或对脂质过氧化或对到达肝脏的CCl4水平有轻微影响或无影响。钙治疗的四氯化碳中毒动物减少四氯化碳诱导的钙增加在肝脏和增加谷胱甘肽水平降低肝毒素在24小时。钙治疗不能预防CCl4诱导的脂肪肝。钙的保护作用是体温依赖性的，但当钙处理的中毒动物保持正常体温时，它们被取消。结果表明，钙离子的保护作用可能与钙螯合作用有关，或者它们可能来自体温的降低。
In agreement with the hypothesis that changes in calcium homeostasis might be significant in late stages of chemically-induced liver cell injury, a calcium chelating agent, Calcion, was able to partially prevent CCl4-induced liver necrosis observed at 24 h, when treatment was given as late as 6 or 10 h after the hepatotoxin. Calcion had minor or no effects on covalent binding of reactive metabolites to cellular components, or on lipid peroxidation or on CCl4levels reaching the liver. Calcion treatment of CCl4-poisoned animals decreased CCl4-induced calcium increases in liver and increased gluthathione levels decreased by hepatotoxin at 24 h. Calcion treatment was not able to prevent CCl4-induced fatty liver. Calcion protective effects were body temperature dependent but they were cancelled when Calcion-treated poisoned animals were kept normothermic. Results suggest that Calcion protective effects might be linked to calcium chelation or alternatively that they might derive from decreases in body temperature.