Genetic mapping of a locus (mass1) causing audiogenic seizures in mice.
Genetic mapping of a locus (mass1) causing audiogenic seizures in mice.
复制标题
引起小鼠听源性癫痫发作的基因座（mass1）的基因图谱。
DOI：
10.1006/geno.1998.5229
复制
发表时间：
1998
期刊：
影响因子：
4.4
通讯作者：
Ptacek,LJ
中科院分区：
文献类型：
--
作者：
Skradski,SL;White,HS;Ptacek,LJ
Frings audiogenic seizure-susceptible mice are a model for sensory-evoked reflex seizures. Their seizure phenotype is characterized by wild running, loss of righting reflex, tonic flexion, and tonic extension in response to high-intensity sound stimulation. The Frings mice represent an inbred colony that has not been genetically characterized. This investigation studied the mode of inheritance for audiogenic seizures by crossing the Frings mouse with the seizure-resistant C57BL/6J mouse. Among the backcross progeny generated by crossing (Frings × C57BL/6J)F1 mice with the Frings strain, 391 of the 836 N2 progeny were audiogenic seizure susceptible, a finding consistent with monogenic inheritance. Genetic mapping and linkage analysis of hybrid mice using MIT microsatellite marker sequences localized the seizure gene, namedmass1for monogenic audiogenic seizure susceptible, to an approximately 3.6 cM interval in the middle of mouse chromosome 13. Linkage ofmass1to chromosome 13 is an important step in identifying the gene associated with a monogenic seizure disorder in mice, which may ultimately lead to a better understanding of the pathophysiology of human seizure disorders.
