Using genotyping and geospatial scanning to estimate recent mycobacterium tuberculosis transmission, United States.
Using genotyping and geospatial scanning to estimate recent mycobacterium tuberculosis transmission, United States.
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使用基因分型和地理空间扫描来估计美国最近的结核分枝杆菌传播。
DOI：
10.3201/eid1803.111107
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发表时间：
2012-03
影响因子：
11.8
通讯作者：
Navin TR
中科院分区：
文献类型：
--
作者：
Moonan PK;Ghosh S;Oeltmann JE;Kammerer JS;Cowan LS;Navin TR
这些工具可以将资源引导到传播率高的人群。为了确定在美国报告的结核病（TB）病例中由于最近传播的比例，我们进行了一项横断面研究，以检查2005年1月至2009年12月期间报告的具有完整基因型结果（spoligotyping和12位点分枝杆菌散布重复单位可变数目串联重复分型）的培养阳性TB病例。最近转交的案件被定义为在具有统计意义的地理空间区域内报告了匹配结果的案件（通过3年滑动窗口内的空间跨度统计确定）。在美国报告的结核病病例中，约有四分之一可归因于最近的传播。最近传播风险最大的群体似乎是男子、在美国出生的人、少数种族或族裔群体的成员、滥用药物的人和无家可归者。了解结核病的传播动态并制定快速检测这些人群中最近传播的策略对于在美国消除结核病至关重要。
These tools may enable direction of resources to populations with high transmission rates. To determine the proportion of reported tuberculosis (TB) cases due to recent transmission in the United States, we conducted a cross-sectional study to examine culture-positive TB cases with complete genotype results (spoligotyping and 12-locus mycobacterial interspersed repetitive unit–variable-number tandem repeat typing) reported during January 2005–December 2009. Recently transmitted cases were defined as cases with matching results reported within statistically significant geospatial zones (identified by a spatial span statistic within a sliding 3-year window). Approximately 1 in 4 TB cases reported in the United States may be attributed to recent transmission. Groups at greatest risk for recent transmission appear to be men, persons born in the United States, members of a minority race or ethnic group, persons who abuse substances, and the homeless. Understanding transmission dynamics and establishing strategies for rapidly detecting recent transmission among these populations are essential for TB elimination in the United States.