Evaluation of tetraethylammonium bicarbonate as a phase-transfer agent in the formation of [18F]fluoroarenes
Evaluation of tetraethylammonium bicarbonate as a phase-transfer agent in the formation of [18F]fluoroarenes
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DOI：
10.1016/j.jfluchem.2012.07.015
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发表时间：
2012-11-01
影响因子：
1.9
通讯作者：
Carroll, Michael A.
中科院分区：
文献类型：
--
作者：
Reed, Christopher D.;Launay, Guillaume G.;Carroll, Michael A.
四乙基碳酸氢铵，Et4N中心圆点HCO3，被发现是一种有效的相转移剂，在微型反应器中，用于从一系列前体(二芳基碘盐、硝化芳烃和[F-19]氟芳烃)生产[F-18]氟芳烃。这项研究确立了Et4N中心点HCO3作为传统相转移系统-Kyptofix(R)222/K2CO3-的实用替代方案，因为放射性标记产品是以可比较的放化产额产生的。Et4N中心点HCO3的使用还消除了传统系统经常遇到的微反应器堵塞，从而显著提高了生产率。(C)2012爱思唯尔B.V.保留所有权利。
Tetraethylammonium bicarbonate, Et4N center dot HCO3, was found to be an efficient phase-transfer agent, in a microreactor, for the production of [F-18]fluoroarenes from a range of precursors (diaryliodonium salt, nitroarene and [F-19]fluoroarene). This study has established Et4N center dot HCO3 as a practical alternative to the conventional phase-transfer system - Kryptofix (R) 222/K2CO3 - as the radiolabelled products were generated in comparable radiochemical yields. The use of Et4N center dot HCO3 also dramatically increased productivity by eliminating the frequent blockages of the microreactor experienced with the traditional system. (C) 2012 Elsevier B.V. All rights reserved.