Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids.
Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids.
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DOI：
10.1084/jem.144.6.1689
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发表时间：
1976-12-01
期刊：
影响因子：
--
通讯作者：
Reich E
中科院分区：
文献类型：
--
作者：
Hamilton J;Vassalli JD;Reich E
向小鼠腹腔注射石棉纤维可诱导含有巨噬细胞的渗出物形成，巨噬细胞可产生纤溶酶原激活剂。同样，在体外将石棉添加到巨噬细胞培养物中可以刺激纤溶酶原激活物的分泌；在这些条件下，溶菌酶和溶酶体酶的合成和分泌没有改变。暴露于石棉的巨噬细胞增强的纤溶酶原激活物的分泌被低浓度的抗炎类固醇抑制。
Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.