Performance evaluation of MIND demons deformable registration of MR and CT images in spinal interventions.
Performance evaluation of MIND demons deformable registration of MR and CT images in spinal interventions.
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DOI：
10.1088/0031-9155/61/23/8276
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发表时间：
2016-12-07
影响因子：
3.5
通讯作者：
Siewerdsen JH
中科院分区：
文献类型：
--
作者：
Reaungamornrat S;De Silva T;Uneri A;Goerres J;Jacobson M;Ketcha M;Vogt S;Kleinszig G;Khanna AJ;Wolinsky JP;Prince JL;Siewerdsen JH
目标解剖结构和邻近神经和血管组织的准确术中定位对于安全、有效的手术至关重要，并且多模态可变形配准可用于通过将术前CT或MR图像与术中图像融合来识别此类解剖结构。一种可变形的图像配准方法已被开发出来，以估计术前MR和术中CT之间的粘弹性神经元形态，使用模态无关的邻域描述符（MIND）和Huber度量鲁棒配准。该方法称为MIND Demons，通过在多分辨率方案中交替高斯-牛顿优化和吉洪诺夫正则化来优化约束对称能量泛函，并将先验的平滑性，测地线和可逆性结合起来。配准性能进行了评估的MIND恶魔方法与对称的能量配方相比，一个不对称的形式，和各向异性MR体素大小的敏感性进行了分析，在仿真图像引导的脊柱手术相比，一个自由形式的变形（FFD）的方法，使用局部互信息（LMI）的体模实验。在一项涉及15名接受颈椎、胸椎和腰椎介入治疗的患者的临床研究中对性能进行了确认。对称MIND Demons制剂的目标配准误差（TRE）[1.3 ± 0.8 mm（中位数±四分位数）]优于非对称形式[3.6 ± 4.4 mm]。该方法对各向异性MR体素尺寸的敏感性相当小，MR切片厚度范围为0.9 - 9.9 mm的中位TRE范围为1.3 - 2.9 mm，而相同范围内LMI FFD的TRE = 3.2 - 4.1 mm。临床数据评估表明，在所有15个具有真实变形的病例中，亚体素TRE（< 2 mm）保留了具有亚体素可逆性（0.001 mm）和正定空间雅可比矩阵的拓扑结构。因此，该方法对MR中的现实各向异性分辨率特性具有鲁棒性，并且产生适合于图像引导脊柱手术中的应用的配准精度。
Accurate intraoperative localization of target anatomy and adjacent nervous and vascular tissue is essential to safe, effective surgery, and multimodality deformable registration can be used to identify such anatomy by fusing preoperative CT or MR images with intraoperative images. A deformable image registration method has been developed to estimate viscoelastic diffeomorphisms between preoperative MR and intraoperative CT using modality-independent neighborhood descriptors (MIND) and a Huber metric for robust registration. The method, called MIND Demons, optimizes a constrained symmetric energy functional incorporating priors on smoothness, geodesics, and invertibility by alternating between Gauss-Newton optimization and Tikhonov regularization in a multiresolution scheme. Registration performance was evaluated for the MIND Demons method with a symmetric energy formulation in comparison to an asymmetric form, and sensitivity to anisotropic MR voxel-size was analyzed in phantom experiments emulating image-guided spine-surgery in comparison to a free-form deformation (FFD) method using local mutual information (LMI). Performance was validated in a clinical study involving 15 patients undergoing intervention of the cervical, thoracic, and lumbar spine. The target registration error (TRE) for the symmetric MIND Demons formulation [1.3 ± 0.8 mm (median ± interquartile)] outperformed the asymmetric form [3.6 ± 4.4 mm]. The method demonstrated fairly minor sensitivity to anisotropic MR voxel size, with median TRE ranging 1.3 – 2.9 mm for MR slice thickness ranging 0.9 – 9.9 mm, compared to TRE = 3.2 – 4.1 mm for LMI FFD over the same range. Evaluation in clinical data demonstrated sub-voxel TRE (< 2 mm) in all fifteen cases with realistic deformations that preserved topology with sub-voxel invertibility (0.001 mm) and positive-determinant spatial Jacobians. The approach therefore appears robust against realistic anisotropic resolution characteristics in MR and yields registration accuracy suitable to application in image-guided spine-surgery.
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