Relationship between measures of dementia severity and observation of daily life functioning as measured with the assessment of motor and process skills (AMPS)
Relationship between measures of dementia severity and observation of daily life functioning as measured with the assessment of motor and process skills (AMPS)
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DOI：
10.1159/000111694
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Verhey, Frans R. J.
中科院分区：
文献类型：
--
作者：
Bouwens, Sharon F. M.;van Heugten, Caroline M.;Verhey, Frans R. J.
背景：认知功能障碍大多被认为是痴呆的核心症状，但其他几个领域(如日常功能)与评估痴呆的严重程度同样相关。这些领域之间的关系尚不清楚。在痴呆症患者中，运动与过程技能评估(AMPS)是一种相对未被探索的工具，通过直接观察来测量严重程度。目的：研究AMPS与几种常用的痴呆严重程度评估指标的分数之间的关系，并考察神经精神症状对认知障碍患者这种关系的可能影响。方法：使用118例认知障碍患者的横断面数据；认知(MMSE；收集和分析CAMCOG)、全球严重程度(GDS)、日常生活功能(IADL)和神经精神症状(NPI)，并进行相关和回归分析。结果：MMSE、CAMCOG和GDS得分与AMPS过程能力得分呈中度相关。这些测量解释了AMPS评分中27%至44%的差异。冷漠的存在影响了认知测量和AMPS评分之间的关联。结论：常用的痴呆症严重程度测量仅与日常活动表现的观察适度相关。这强调了直接观察痴呆症患者日常活动的必要性。几种评估痴呆症严重程度的方法之间的关系需要进一步研究。版权所有(C)2007 S.Karger AG，巴塞尔
Background: Cognitive impairment is mostly regarded as the core symptom of dementia, but several other domains (such as daily functioning) are equally relevant to assess the severity of dementia. The relationship between these domains is unclear. The Assessment of Motor and Process Skills (AMPS) is a relatively unexplored instrument in people with dementia, measuring severity by direct observation.Objective: To study the relationship between the AMPS and scores on several commonly used outcome measures for the assessment of dementia severity, and to examine the possible influence of neuropsychiatric symptoms on these relationships in patients with cognitive disorders.Methods: Crosssectional data of 118 patients with cognitive disorders were used; data on cognition (Mini- Mental State Examination, MMSE; CAMCOG), global severity (Global Deterioration Scale, GDS), daily life functioning (Instrumental Activities of Daily Living, IADL), and neuropsychiatric symptoms (Neuropsychiatric Inventory, NPI) were collected and analyzed using correlation and regression analyses. Different combinations of the severity measures were tested for their ability to predict the AMPS process ability scores.Results: Scores on the MMSE, CAMCOG and GDS were moderately associated with the AMPS process ability score. These measures explained between 27 and 44% of the variance in the AMPS score. The presence of apathy influenced the association between the cognitive measures and the AMPS score.Conclusion: Commonly used measures of dementia severity are only moderately associated with observation of performance on daily activities. This underlines the need for direct observation of daily activities in dementia patients. This relationship between several approaches of assessing dementia severity needs further study. Copyright (c) 2007 S. Karger AG, Basel