From Egg to Embryo; determinative events in early development. By J. M. W. Slack. Pp. 241. (Cambridge University Press, August 1983.) £25.00, $49.50
From Egg to Embryo; determinative events in early development. By J. M. W. Slack. Pp. 241. (Cambridge University Press, August 1983.) £25.00, $49.50
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从卵到胚胎；J. M. W. Slack，第 241 页。（剑桥大学出版社，1983 年 8 月）25.00 英镑，49.50 美元。
DOI：
10.1113/expphysiol.1984.sp002828
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发表时间：
1984
影响因子：
2.7
通讯作者：
A. Warner
中科院分区：
文献类型：
--
作者：
A. Warner
从蛋到胚胎；早期发育的决定性事件。由JMW Slak提供。PP.241.剑桥大学出版社，1983年8月。GB 25.00，49.50美元。早期发育包括胚胎内细胞的许多决定：哪一层胚层？每个胚层中的哪种细胞类型？什么时候分家？什么时候搬家？何时才能实现差异化？这本书的目的是阐述我们所知道的胚胎细胞在胚胎内制定身体计划时做出的各种发育决定。本课程面向发育生物学的本科生和研究生，以及对这一研究领域感兴趣的其他生物学家。这本书分为三个部分。第一部分涉及用于定义细胞从胚胎细胞到分化细胞类型的过程中所经历的各种状态的术语，并介绍了用于阐明这些状态的方法。第二部分简要介绍了我们对不同物种胚胎的发育决策的了解，第三部分讨论了“模型构建”，以此来探讨这一发育生物学领域提出的问题。我觉得这很有帮助，我认为作者很好地尝试定义了诸如规范和确定之类的术语，这些术语经常被不同的人以略有不同的方式使用，并在过去导致了相当大的融合。这让我想起了一次会议，在那次会议上，七位发育生物学家花了两天时间，除了“承诺”、“规范”和“决心”之外，什么都不讨论。这三个词被赋予的含义几乎是无限的。我还认为他对命运图的用处和局限性的仔细定义是非常有价值的。命运图对于告诉我们细胞在发育中起什么作用是必不可少的，但对它们是如何做到这一点的信息用处很少。正如作者所意识到的，对各种物种中的胚胎学事件的描述不可避免地相当简短。然而，问题已经明确列出，明确和混淆的领域也已确定。重点放在经典胚胎学的实验上，他提请注意目前分子生物学家和经典胚胎学家之间存在着相当大的差距。也许这本书将有助于证明为什么会存在这种差距。
From Egg to Embryo; determinative events in early development. By JMW SLACK. Pp. 241.(Cambridge University Press, August 1983.)£ 25.00, $49.50. Early development encompasses many decisions by cells within the embryo: which germ layer? which cell type within each germ layer? when to divide? when to move? when to differentiate? This book aims to set out what we know about the various developmental decisions made by embryonic cells as the body plan is laid out within the embryo. It is intended forundergraduates andpost-graduates in developmental biology and for other biologists interested in this area of research. The book is arranged in three parts. The first deals with the terms used to define the various states that cells pass through on their way from embryonic cell to differentiated cell type and introduces the methods used to elucidate these states. Part Two gives a brief account of what we know about developmental decision making in the embryos of various species and Part Three deals with'model building'as a way of approaching the problems posed by this area of developmental biology. I found this layouthelpful and thought the author had made a good job of trying to define terms such as specification and determination which are often used in slightly different ways by different people and have lead to considerableconfusion in the past. It reminded me of a meeting in which seven developmental biologists spent two days discussing nothing other than'commitment','specification'and'determination'. The shades of meaning given to these three words were almost infinite. I also thought his careful definition of the usefulness and limitations of the fate map-essential for telling us what cells do in development, but oflittle use for information on how they do it-extremely worthwhile.As the author is aware, the descriptions of embryological events in the various species are inevitably rather brief. However the issues are clearly set out and the areas of clarity and confusion identified. The emphasis is on the experiments of classical embryology and he draws attention to the considerable gap there is at present between the molecular biologists and the classical embryologists. Perhaps this book will help to demonstrate why this gap exists.